Childhood obesity.
Childhood obesity.
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DOI：
10.1016/s0140-6736(10)60171-7
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发表时间：
2010-05-15
期刊：
影响因子：
168.9
通讯作者：
Kimm, Sue Y. S.
中科院分区：
文献类型：
--
作者：
Han, Joan C.;Lawlor, Debbie A.;Kimm, Sue Y. S.
在过去的30年里，世界范围内儿童肥胖的患病率大大增加。在儿童中出现的疾病，如2型糖尿病，被认为是肥胖流行的结果。在了解食欲控制的遗传学和生理学方面取得了很大进展，并由此阐明了一些罕见的肥胖综合征的原因。然而，到目前为止，这些罕见的疾病在如何预防或逆转大多数儿童肥胖方面只教会了我们有限的经验。考虑到当今儿童久坐不动的生活方式，在人口水平上，卡路里摄入量和活动建议需要重新评估和更好地量化。对于个人治疗，考虑到对“能量差距”的不断发展的认识，目前推荐的卡路里处方可能过于保守。虽然预防和治疗方面的研究质量有所提高，但仍需要进行高质量的多中心长期随访试验。同时，旨在增加能量消耗和减少摄入的预防和治疗方法需要继续下去。最近，儿童肥胖患病率的螺旋式增长可能正在减弱。因此，需要在各方面作出更大的努力，以继续这一可能令人兴奋的趋势。
The worldwide prevalence of childhood obesity has increased greatly over the past 3 decades. The increasing occurrence in children of disorders, such as type 2 diabetes, is believed to be a consequence of this obesity epidemic. Much progress has been made in understanding the genetics and physiology of appetite control and from this, the elucidation of the causes of some rare obesity syndromes. However, these rare disorders have so far taught us only limited lessons on how to prevent or reverse obesity in most children. Calorie intake and activity recommendations need to be re-assessed and better quantified, on a population level, given the more sedentary life of children today. For individual treatment, the currently recommended calorie prescriptions may be too conservative given the evolving insight on the “energy gap.” Whilst quality of research in both prevention and treatment has improved, there is still a need for high-quality multi-centre trials with long-term follow-up. Meanwhile, prevention and treatment approaches that aim to increase energy expenditure and decrease intake need to continue. Most recently, the spiralling increase in obesity prevalence may be abating for children. Thus, even greater efforts need to be made on all fronts to continue this potentially exciting trend.