Ruthenium-Catalyzed (2+2) Intramolecular Cycloaddition of Allenenes
Ruthenium-Catalyzed (2+2) Intramolecular Cycloaddition of Allenenes
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DOI：
10.1021/ja200784n
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发表时间：
2011-05-25
影响因子：
15
通讯作者：
Mascarenas, Jose L.
中科院分区：
文献类型：
--
作者：
Gulias, Moises;Collado, Alba;Mascarenas, Jose L.
报道了铼催化的联烯和烯烃的（2 + 2）分子内环加成反应。我们已经发现，钌络合物RuH 2Cl 2（（PPr 3）-Pr 1）（2）的使用对于所观察到的反应性是至关重要的，该钌络合物以前在催化应用中未被注意到。该反应在温和的条件下进行，是完全非对映选择性的，提供了一个实际的进入各种双环[3.2.0]庚烷骨架具有环丁烷环。
We report a ruthenium-catalyzed (2 + 2) intramolecular cycloaddition of allenes and alkenes. We have found that the use of the ruthenium complex RuH2Cl2((PPr3)-Pr-i)(2), which has previously gone unnoticed in catalytic applications, is crucial for the observed reactivity. The reaction proceeds under mild conditions and is fully diastereoselective, providing a practical entry to a variety of bicyclo[3.2.0]heptane skeletons featuring cyclobutane rings.