Establishment of KEIOi005-A iPSC line from urine-derived cells (UDCs) of a mild Alzheimer's disease (AD) donor with multiple risk SNPs for sporadic Alzheimer's disease (sAD)
Establishment of KEIOi005-A iPSC line from urine-derived cells (UDCs) of a mild Alzheimer's disease (AD) donor with multiple risk SNPs for sporadic Alzheimer's disease (sAD)
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利用轻度阿尔茨海默病 (AD) 供体的尿源性细胞 (UDC) 建立 KEIOi005-A iPSC 系，该细胞具有散发性阿尔茨海默病 (SAD) 的多个风险 SNP
DOI：
10.1016/j.scr.2022.102802
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Hideyuki Okano
中科院分区：
文献类型：
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作者：
Sopak Supakul;Nicolas Leventoux;Hajime Tabuchi;Masaru Mimura;Daisuke Ito;Sumihiro Maeda;Hideyuki Okano
散发性阿尔茨海默病（sAD）是一种神经退行性疾病，在痴呆患者中发病率最高。全基因组关联研究表明，sAD 的遗传风险因素由许多单核苷酸多态性 (SNP) 组成。在此，我们从一名轻度阿尔茨海默病 (AD) 患者的尿源性细胞 (UDC) 中产生了 KEIOi005-A 诱导的多能干细胞 (iPSC) 系，该患者具有多个 sAD 风险 SNP，包括 T > C 杂合 APOEε3/ε4 (rs429358)、A > G 杂合 BIN1(rs744373) 和 T > G纯合MS4A6A(rs610932)。建立的 iPSC 系表现出正常的干性和多能性，可用于 AD 的体外疾病模型。
Sporadic Alzheimer’s disease (sAD) is a neurodegenerative disease that has the highest prevalence among patients with dementia. The genetic risk factors for sAD are comprised of many single nucleotide polymorphisms (SNPs), as indicated by genome-wide association studies. Herein, we generated the KEIOi005-A-induced pluripotent stem cell (iPSC) line from urine-derived cells (UDCs) of a mild Alzheimer’s disease (AD) patient with multiple sAD risk SNPs comprising T > C heterozygousAPOEε3/ε4 (rs429358), A > G heterozygousBIN1(rs744373), and T > G homozygousMS4A6A(rs610932). The established iPSC line demonstrates normal stemness and pluripotency and can be used forin vitrodisease modeling of AD.