Plant-based vaccines against viruses.

Plant-based vaccines against viruses.
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DOI:
10.1186/s12985-014-0205-0
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发表时间:
2014-12-03
期刊:
影响因子:
4.8
通讯作者:
Rybicki EP
Rybicki EP
中科院分区:
医学3区
文献类型:
--
作者:
Rybicki EP

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植物制造或“生物农业”病毒疫苗是植物分子农业技术最早的产品之一,并且仍然是该领域成功的最光明前景。对于许多候选的病毒性兽用疫苗,存在原理和功效的证据;植物制造的病毒抗原和单克隆抗体用于治疗动物甚至人类病毒性疾病的用途也得到了很好的确立。本文探讨了最近在病毒疫苗和疗法的生物农业方面取得的一些比较突出的进展,包括最近使用ZMapp治疗埃博拉病毒感染,并探讨了该技术未来可能的一些应用。
Plant-made or “biofarmed” viral vaccines are some of the earliest products of the technology of plant molecular farming, and remain some of the brightest prospects for the success of this field. Proofs of principle and of efficacy exist for many candidate viral veterinary vaccines; the use of plant-made viral antigens and of monoclonal antibodies for therapy of animal and even human viral disease is also well established. This review explores some of the more prominent recent advances in the biofarming of viral vaccines and therapies, including the recent use of ZMapp for Ebolavirus infection, and explores some possible future applications of the technology.
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