Proposal for a Power Supply Line-free Mass Sensor for Measuring Total Protein in Human Saliva
Proposal for a Power Supply Line-free Mass Sensor for Measuring Total Protein in Human Saliva
复制标题
用于测量人类唾液中总蛋白的无电源线质量传感器的提案
DOI：
10.1166/sl.2014.3165
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
and Yuta Kimura
中科院分区：
文献类型：
--
作者：
Masaki Yamaguchi;and Yuta Kimura
本研究的目的是展示一种新的设计的质量传感器与微束谐振器，没有电源线。该无线质量传感器包括一个微束谐振器和一个单独的压电元件，用于激发谐振器中的振动。电力被用来驱动压电元件，使微束谐振器不受电源线的影响。目标分子附着在微束谐振器上，改变其谐振频率。采用有限元法进行特征值-特征向量评估，设计了微束谐振腔的几何形状和尺寸。微束谐振腔的尺寸为4 × 0.4 × 0.4 mm3，由AT-Cut晶体制成自由-自由棒型结构。微束谐振器工作在主振动模式下。用无线质量传感器测定人唾液样品中总蛋白的浓度。如果使用频率分辨率为1 mHz的光学位移传感器，估计使用无线质量传感器可以实现76.2 ng/ml的灵敏度。
The purpose of this research is to demonstrate a new design for a mass sensor with a microbeam resonator that is free from power supply lines. The line-free mass sensor comprises a microbeam resonator and a separate piezoelectric element used to excite vibrations in the resonator. Electrical power is used to actuate the piezoelectric element, leaving the microbeam resonator free from power lines. Target molecules become attached to the microbeam resonator changing its resonant frequency. The geometrical shape and dimensions of the microbeam resonator were designed using an eigenvalue-eigenvector evaluation employing a finite element method. The size of the microbeam resonator is 4 × 0.4 × 0.4 mm3 and it was fabricated from an AT-Cut crystal in a free-free bar type configuration. The microbeam resonator was operated in the primary mode of vibration. The concentration of total protein in human saliva samples was measured using the line-free mass sensor. If an optical displacement sensor with a frequency resolution of 1 mHz is used, it is estimated that a sensitivity of 76.2 ng/ml can be achieved with the line-free mass sensor.