Undernutrition and childhood infections: a prospective study of childhood infections in relation to growth in the Sudan
Undernutrition and childhood infections: a prospective study of childhood infections in relation to growth in the Sudan
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DOI：
10.1080/713794561
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发表时间：
2000-09-01
期刊：
影响因子：
3.8
通讯作者：
Fawzi, WW
中科院分区：
文献类型：
--
作者：
Kossmann, J;Nestel, P;Fawzi, WW
在28753名苏丹学龄前儿童中前瞻性地研究了腹泻和呼吸道感染与线性和重量生长之间的关系。儿童感染与身高、体重以及6个月内身高和体重的增加呈显著负相关。在调整了年龄、性别、社会经济地位、饮食变量和既往发病率后，他们也与发育迟缓显著正相关。与没有这些症状的儿童相比，腹泻儿童的身高平均低17 mm（95% CI [-19 -15]），并发咳嗽儿童的身高平均低11 mm（95% CI [-3 -9]）。发病率和达到的体重之间的关联是显着的腹泻和复杂的咳嗽，但有症状和无症状的儿童之间的差异可以忽略不计。在营养正常的腹泻、发热性腹泻和发热儿童中，6个月后发育不良的风险分别是无这些症状儿童的1.38倍（95%CI [1.20 1.59]）、1.29倍（95%CI [0.97 1.72]）和1.32倍（95%CI [1.13 1.54]）。腹泻或复杂的咳嗽和那些没有症状的儿童之间的身高差异随年龄的增长而增加，是较大的非母乳喂养的儿童相比，母乳喂养的children.Conclusion：结果强调，需要减少儿童发病率，以防止损害的生长和发育。
The relationships between both diarrhoea and respiratory infections and linear and ponderal growth were prospectively examined among 28 753 Sudanese pro-school children. Childhood infections were significantly and inversely associated with attained height and attained weight and gain in height and weight over a 6-mo period. They were significantly and positively associated also with stunting after adjusting for age, gender, socio-economic status, dietary variables and previous morbidity. Attained height was on average 17 mm lower (95% CI [-19 -15]) for children with diarrhoea and 11 mm lower (95% CI [-3 -9]) for children with complicated cough than for those without these symptoms. The association between morbidity and attained weight was significant for diarrhoea and complicated cough, but the differences between children with and without symptoms were negligible. The risk of being stunted 6 mo later was 1.38 times (95% CI [1.20 1.59]), 1.29 times (95% CI [0.97 1.72]) and 1.32 times (95% CI [1.13 1.54]) greater among normally-nourished children with diarrhoea, febrile diarrhoea and fever, respectively, than among children without these symptoms. The difference in attained height between children with diarrhoea or complicated cough and those without symptoms increased with age, and was larger among the non-breastfed children compared with breastfed children.Conclusion: The results underline the need to reduce child morbidity to prevent the impairment of growth and development.