Versatile new ion source for the analysis of materials in open air under ambient conditions
Versatile new ion source for the analysis of materials in open air under ambient conditions
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DOI：
10.1021/ac050162j
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发表时间：
2005-04-15
影响因子：
7.4
通讯作者：
Durst, HD
中科院分区：
文献类型：
--
作者：
Cody, RB;Laramée, JA;Durst, HD
已经开发了一种新的离子源，用于在环境压力和地面潜力下对材料的快速无接触分析。新来源称为DART（用于“实时直接分析”），基于电子或振动激发态物种与试剂分子以及极性或非极性分析物的反应。 DART已安装在高分辨率飞行时间质谱仪（TOFM）上，该质谱仪通过精确的质量测量提供了提高的选择性和准确的元素组成分配。尽管DART已应用于对气体，液体和固体的分析，但独特的应用是在不需要样品制备的情况下直接检测到表面上的化学物质，例如擦拭或溶剂提取。 DART在取样数百种化学物质方面取得了成功，包括化学剂及其特征，药物，代谢物，肽和寡糖，合成有机物，有机金属，滥用药物，爆炸物和有毒工业化学品。在各种表面上检测到这些物种，例如混凝土，沥青，人类皮肤，货币，航空公司登机牌，名片，水果，蔬菜，香料，饮料，体液，体液，园艺叶子，鸡尾酒，鸡尾酒玻璃和衣服。 DART不采用放射性组件，并且使用基于放射性同位素的电离设备更通用。由于其响应是瞬时的，DART提供了实时信息，筛选或高通量的关键要求。
A new ion source has been developed for rapid, noncontact analysis of materials at ambient pressure and at ground potential. The new source, termed DART (for "Direct Analysis in Real Time"), is based on the reactions of electronic or vibronic excited-state species with reagent molecules and polar or nonpolar analytes. DART has been installed on a high-resolution time-of-flight mass spectrometer (TOFMS) that provides improved selectivity and accurate elemental composition assignment through exact mass measurements. Although DART has been applied to the analysis of gases, liquids, and solids, a unique application is the direct detection of chemicals on surfaces without requiring sample preparation, such as wiping or solvent extraction. DART has demonstrated success in sampling hundreds of chemicals, including chemical agents and their signatures, pharmaceutics, metabolites, peptides and oligosaccharides, synthetic organics, organometallics, drugs of abuse, explosives, and toxic industrial chemicals. These species were detected on various surfaces, such as concrete, asphalt, human skin, currency, airline boarding passes, business cards, fruits, vegetables, spices, beverages, body fluids, horticultural leaves, cocktail glasses, and clothing. DART employs no radioactive components and is more versatile than devices using radioisotope-based ionization. Because its response is instantaneous, DART provides real-time information, a critical requirement for screening or high throughput.