A Histologic and Immunohistochemical Study Describing the Diversity of Tumors Classified as Sinonasal High-grade Nonintestinal Adenocarcinomas
A Histologic and Immunohistochemical Study Describing the Diversity of Tumors Classified as Sinonasal High-grade Nonintestinal Adenocarcinomas
复制标题
DOI：
10.1097/pas.0b013e31821cbd72
复制
发表时间：
2011-07-01
影响因子：
5.6
通讯作者：
Carlson, Diane L.
中科院分区：
文献类型：
--
作者：
Stelow, Edward B.;Jo, Vicky Y.;Carlson, Diane L.
非肠鼻窦腺癌 (SNAC) 的特征尚不清楚，高级别非肠鼻窦腺癌的报道也很少。在这里，我们回顾一下我们在这些肿瘤方面的经验。从 22 名男性和 5 名女性中鉴定出 27 例高级别非肠道 SNAC。年龄范围为 22 至 83 岁（平均值 +/- 1 标准差 = 54.7 +/- 18.6 岁；中位数 = 60 岁）。累及鼻腔及鼻窦者13例，仅累及鼻腔者10例，仅累及鼻窦者4例。大多数病例有明显的细胞学和核多形性、丰富的有丝分裂活性和坏死；然而，这些特征并不统一。尽管组织学上存在异质性，但复发性生长模式与该地区的其他肿瘤相似。肿瘤缺乏 CDX2 和 CK20 免疫反应性（除了罕见的 CK20 免疫反应性细胞）。高级别非肠道 SNAC 在男性中更为常见，尽管其发生的年龄范围很广，但在老年人中更为常见。在组织学上，它们表现出很大的异质性。
Nonintestinal sinonasal adenocarcinomas (SNACs) are somewhat poorly characterized and high-grade nonintestinal SNACs have been only rarely reported. Here, we review our experience with these tumors. Twenty-seven cases of high-grade nonintestinal SNACs were identified from 22 men and 5 women. Ages ranged from 22 to 83 years (mean +/- 1 standard deviation = 54.7 +/- 18.6 y; median = 60 y). Thirteen cases involved the nasal cavity and sinuses, 10 involved the nasal cavity only, and 4 involved sinuses only. Most cases had marked cytologic and nuclear pleomorphism, abundant mitotic activity, and necrosis; however, these features were not uniform. Although histologically heterogeneous, recurrent growth patterns were seen that resembled other neoplasms of the area. Tumors lacked CDX2 and CK20 immunoreactivity (aside from rare CK20 immunoreactive cells). High-grade nonintestinal SNACs are more common in men and, although they occur over a wide age range, they are much more common in older individuals. Histologically, they show a great deal of heterogeneity.