Sodium Tetraarylborates as Effective Nucleophiles in Rhodium/Diene-Catalyzed 1,4-Addition to β,β-Disubstituted α,β-Unsaturated Ketones: Catalytic Asymmetric Construction of Quaternary Carbon Stereocenters
Sodium Tetraarylborates as Effective Nucleophiles in Rhodium/Diene-Catalyzed 1,4-Addition to β,β-Disubstituted α,β-Unsaturated Ketones: Catalytic Asymmetric Construction of Quaternary Carbon Stereocenters
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DOI：
10.1021/ja905432x
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发表时间：
2009-09-30
影响因子：
15
通讯作者：
Hayashi, Tamio
中科院分区：
文献类型：
--
作者：
Shintani, Ryo;Tsutsumi, Yosuke;Hayashi, Tamio
描述了铑催化的四芳基硼酸钠与β，β-二取代的α，β-不饱和酮的1，4-加成反应。高效的不对称催化也已实现通过采用一个容易获得的手性二烯配体，导致建设具有高对映体选择性的季碳立体中心。
A rhodium-catalyzed 1,4-addition of sodium tetraarylborates to beta,beta-disubstituted alpha,beta-unsaturated ketones is described. Highly efficient asymmetric catalysis has also been achieved by employing a readily available chiral diene ligand, leading to the construction of quaternary carbon stereocenters with high enantioselectivity.