Effects of dopamine on chemoreflexes in breathing.
Effects of dopamine on chemoreflexes in breathing.
复制标题
多巴胺对呼吸化学反射的影响。
DOI：
10.1152/jappl.1981.50.4.892
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Lahiri,S
中科院分区：
文献类型：
--
作者：
Nishino,T;Lahiri,S
在用α-氯醛糖麻醉的猫中，研究了静脉输注多巴胺（20 μ g.min）对连续水平的等二氧化碳缺氧和高氧高二氧化碳的稳态兴奋性和颈动脉化学感受器反应的影响。多巴胺输注后，通气量在约20秒内最大程度下降。此后，影响减弱并稳定下来。多巴胺输注终止后立即增加通气量。这些反射反应小于相应的颈动脉化学感受器反应。多巴胺输注的稳态效应是在所有水平的动脉氧分压下减少通气，在缺氧期间的减少大于在高氧期间的减少。双侧颈动脉窦神经节显着减少，但并没有取消多巴胺对高氧通气的抑制作用。因此，多巴胺输注引起的兴奋性抑制并不完全是由于其对颈动脉化学感受器的影响。多巴胺降低了对连续水平的高碳酸血症的反应，幅度相同，但不改变反应曲线的斜率。化学感受器活性和通气量之间的稳态关系表明，在多巴胺输注过程中，由于其对颈动脉化学感受器活性的抑制作用大于对通气量的抑制作用，随着动脉O2张力的降低，颈动脉化学感受器活性的抑制当量增加。
The effects of intravenous infusion of dopamine (20 microgram.min) on the steady-state ventilatory and carotid chemoreceptor responses to successive levels of isocapnic hypoxia and hyperoxic hypercapnia were investigated in cats anesthetized with alpha-chloralose. Dopamine infusion was followed by a maximal decrease in ventilation in about 20 s. Thereafter, the effect diminished and stabilized. Termination of dopamine infusion was promptly followed by an increase in ventilation. These ventilatory responses were smaller than the corresponding carotid chemoreceptor responses. The steady-state effect of dopamine infusion was to diminish ventilation at all levels of arterial O2 tension, the decrease being greater during hypoxia than that during hyperoxia. Bilateral section of the carotid sinus nerves significantly diminished but did not abolish the inhibitory effect of dopamine on ventilation during hyperoxia. Thus the ventilatory depression due to dopamine infusion is not entirely due to its effect on the carotid chemoreceptors. Dopamine decreased ventilatory responses to successive levels of hypercapnia by the same magnitude without changing the slope of the response curves. The steady-state relationship between chemoreceptor activity and ventilation shows that the ventilatory equivalent for carotid chemoreceptor activity is increased during dopamine infusion because of its greater inhibitory effect on carotid chemoreceptor activity than on ventilation with the decrease of arterial O2 tension.