Aqueous solubility, n-octanol-water partition coefficient, and sorption of five selective serotonin reuptake inhibitors to sediments and soils
Aqueous solubility, n-octanol-water partition coefficient, and sorption of five selective serotonin reuptake inhibitors to sediments and soils
复制标题
DOI：
10.1007/s00128-008-9401-1
复制
发表时间：
2008-08-01
影响因子：
2.7
通讯作者：
Armbrust, Kevin L.
中科院分区：
文献类型：
--
作者：
Kwon, Jeong-Wook;Armbrust, Kevin L.
测定了5种选择性5-羟色胺再摄取抑制剂（SSRIs）的水溶解度（S-w）和正辛醇-水分配系数（K-ow），并采用平衡法研究了它们在有机质含量为0.16%~ 1.77%、pH为5.0 ~ 7.8的2种沉积物和3种土壤中的吸附。SSRIs具有高S-w（3，022 - 15，460 mg/l）和相对低的log K-ow（1.12-1.39）。吸附等温线符合Freundlich方程。除氟伏沙明的最小吸附容量为73%外，所有SSRI的吸附容量均大于91%。有机质含量部分影响吸附，但没有任何SSRI或吸附剂的吸附特性和阳离子交换容量（CEC）或粘土含量之间的相关性。SSRIs的K-f、K-d和log K-oc值范围为39 - 18，342、60 - 42，579和3.35 - 6.02。SSRIs可能表现出混合的吸附机制，如除疏水相互作用外的离子结合。
Aqueous solubilities (S-w) and n-octanol-water partition coefficients (K-ow) of five selective serotonin reuptake inhibitors (SSRIs) were measured and sorption to two sediments and three soils with organic matter contents ranging from 0.16% to 1.77% and pH ranging between 5.0 and 7.8 was investigated using a batch equilibrium method. SSRIs had high S-w (3,022-15,460 mg/l) and relatively low log K-ow (1.12-1.39). Sorption isotherms followed the Freundlich equation. All SSRIs had sorption capacities of greater than 91% except fluvoxamine with a minimum capacity of 73%. Organic matter contents partly affected sorption, however no correlation between sorption characteristics and cation exchange capacity (CEC) or clay content was observed for any SSRI or adsorbent. Values of K-f, K-d, and log K-oc ranged from 39 to 18,342, from 60 to 42,579, and 3.35 to 6.02 for the SSRIs. SSRIs likely exhibit mixed mechanisms of sorption such as ionic binding in addition to hydrophobic interactions.