GOSemSim: an R package for measuring semantic similarity among GO terms and gene products
GOSemSim: an R package for measuring semantic similarity among GO terms and gene products
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DOI：
10.1093/bioinformatics/btq064
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发表时间：
2010-04-01
期刊：
影响因子：
5.8
通讯作者：
Wang, Shengqi
中科院分区：
文献类型：
--
作者：
Yu, Guangchuang;Li, Fei;Wang, Shengqi
基因本体（GO）注释的语义比较提供了计算基因和基因组之间相似性的定量方法，并已成为许多生物信息学分析方法的重要基础。 GOSemSim 是一个 R 包，用于 GO 术语、GO 术语集、基因产物和基因簇之间的语义相似性计算。 GOSemSim 软件包中实现了四种信息内容 (IC) 和基于图形的方法，还支持包括人类、大鼠、小鼠、苍蝇和酵母在内的多种物种。 GOSemSim 提供的功能为应用提供了灵活性，并且可以轻松集成到高通量分析流程中。
The semantic comparisons of Gene Ontology (GO) annotations provide quantitative ways to compute similarities between genes and gene groups, and have became important basis for many bioinformatics analysis approaches. GOSemSim is an R package for semantic similarity computation among GO terms, sets of GO terms, gene products and gene clusters. Four information content (IC)- and a graph-based methods are implemented in the GOSemSim package, multiple species including human, rat, mouse, fly and yeast are also supported. The functions provided by the GOSemSim offer flexibility for applications, and can be easily integrated into high-throughput analysis pipelines.