PLC and PI3K/Akt/mTOR signalling in disease and cancer.
PLC and PI3K/Akt/mTOR signalling in disease and cancer.
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DOI：
10.1016/j.jbior.2014.10.004
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发表时间：
2015-01-01
影响因子：
--
通讯作者：
Cocco, Lucio
中科院分区：
文献类型：
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作者：
Follo, Matilde Y;Manzoli, Lucia;Cocco, Lucio
癌细胞代谢失调，信号通路可能参与其中。例如，PI 3 K/Akt/mTOR与正常增殖和分化相关，并且其改变在利用正常机制克服凋亡的癌细胞中是可检测的。另一方面，磷脂酶C（PLC）家族在细胞生长中也起着关键作用，并且关于这些酶或其下游靶标的任何变化都可能与肿瘤转化相关。本文就PLC和PI 3 K/Akt/mTOR信号转导通路在病理生理中的作用作一综述。
Cancer cell metabolism is deregulated, and signalling pathways can be involved. For instance, PI3K/Akt/mTOR is associated with normal proliferation and differentiation, and its alteration is detectable in cancer cells, that exploit the normal mechanisms to overcome apoptosis. On the other hand, also the family of Phospholipase C (PLC) enzymes play a critical role in cell growth, and any change concerning these enzymes or their downstream targets can be associated with neoplastic transformation. Here, we review the role of PLC and PI3K/Akt/mTOR signal transduction pathways in pathophysiology.