IL-13 is a susceptibility factor for Leishmania major infection
IL-13 is a susceptibility factor for Leishmania major infection
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DOI：
10.4049/jimmunol.164.3.1458
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发表时间：
2000-02-01
影响因子：
4.4
通讯作者：
McKenzie, ANJ
中科院分区：
文献类型：
--
作者：
Matthews, DJ;Emson, CL;McKenzie, ANJ
主要利什曼原虫感染是有用的实验模型，以确定负责Th细胞免疫应答的发展和维持的因素。使用近交系小鼠品系的研究已经确定C57 BL/6小鼠的Till应答特征导致愈合，而BALB/c小鼠由于产生不适当的Th 2应答而不能控制感染。IL-13在转基因小鼠中的过表达使正常抵抗的C57 BL/6小鼠品系对L.即使在没有IL-4表达的情况下也是主要感染。这种易感性与IL-12和IFN-γ表达的抑制相关。此外，使用IL-4、IL-13或IL-13和IL-4表达缺陷的BALB/c小鼠，我们证明IL-13缺陷小鼠对感染具有抗性，并且缺失IL-4和IL-13两者具有累加效应。
Leishmania major infection is useful as an experimental model to define factors responsible for the development and maintenance of Th cell immune responses. Studies using inbred mouse strains have identified that the Till response characteristic of C57BL/6 mice results in healing, whereas BALB/c mice fail to control the infection due to the generation of an inappropriate Th2 response. We now demonstrate that IL-13 is a key factor in determining susceptibility to L, major infection, Overexpression of IL-13 in transgenic mice makes the normally resistant C57BL/6 mouse strain susceptible to L. major infection even in the absence of IL-4 expression. This susceptibility correlates with a suppression of 1L-12 and IFN-gamma expression. Furthermore, using BALB/c mice deficient in the expression of IL-4, IL-13, or both IL-13 and IL-4, we demonstrate that IL-13-deficient mice are resistant to infection and that there is an additive effect of deleting both IL-4 and IL-13.