The Contractile Ring and Furrowing in Dividing Cells
The Contractile Ring and Furrowing in Dividing Cells
复制标题
分裂细胞中的收缩环和沟纹
DOI：
--
复制
发表时间：
1990
影响因子：
5.2
通讯作者：
T. E. Schroeder
中科院分区：
文献类型：
--
作者：
T. E. Schroeder
收缩环是一种细胞骨架结构，被认为对通过皱纹分裂的细胞产生收缩力量，即所有动物细胞和少数植物细胞。尽管它的职能表面上似乎反映在其组织中，但在许多方面仍然知之甚少。为了获得收缩环的完整图像，我们需要更多地了解它的形态和生化特征，它是如何机械地产生皱纹的，它的成分来自哪里，它们是如何组织的，以及它的形成是如何被有丝分裂中的先期事件刺激的。这些都是具有挑战性的目标，尤其是在面临三个障碍的情况下：第一，通过皱纹分裂的细胞在性质上差异很大，而且这种多样性往往与寻找统一的、普遍的机制原理的努力相冲突；第二，检测或量化收缩环必要细节的技术往往过于粗糙和不准确，无法清楚地回答提出的实验问题；第三，急于“解决”皱纹机制模糊了事实和想象之间的区别。在这篇文章中，我将首先重申收缩环的基本组织特征，因为它们建立了一个基本框架，在这个框架中，形态学家可以观察皱纹的其他方面。然后，我将简要地考虑收缩环的可能起源，以及被认为刺激其形成的事件。最后，我将讨论一种全球性的细胞皮质收缩现象，这种现象发生在起皱之前，它提出了一组关于起皱和其他相关收缩的特殊问题。我敦促任何可能对《犁沟》感兴趣的读者彻底查阅大量的原创文献，但对所写的内容保持开放的心态。
The contractile ring is the cytoskeletal structure believed to generate the constriction force for cells that divide by furrowing, namely, all animal cells and a few plant cells. Although its function seems superficially to be reflected in its organization, in many ways it remains poorly understood. To gain an integrated picture of the contractile ring, we need to know a great deal more about what it is morphologically and biochemically, how it works mechanically to produce a furrow, where its components come from and how they are organized, and how its formation is stimulated by antecedent events in mitosis. These are challenging goals, especially in the face of three obstacles: first, the cells that divide by furrowing vary widely in character and the diversity tends to conflict with efforts to find unifying, universal principles of mechanism; second, the techniques for detecting or quantifying the necessary details of the contractile ring are often too crude and imprecise to answer clearly the experimental questions that are asked, and third, the impatience to “solve” the mechanism of furrowing has blurred the distinction between facts and imagination. In this article I will first reiterate the contractile ring’s basic organizational features, for they establish the principle framework in which a morphologist views other aspects of furrowing. I will then briefly consider possible origins of the contractile ring as well as the events that are thought to stimulate its formation. Finally, I will discuss a global contractile phenomenon of the cell cortex that precedes furrowing and that poses a special set of questions concerning furrowing and other allied constriction. I urge any reader who might be seriously interested in furrowing to consult thoroughly the extensive original literature and yet to maintain an open mind about what has been written.
游离海胆卵裂球细胞表面和皮层的接触无关极化。
影响因子：
2.7
作者：
Schroeder,TE
通讯作者：
Schroeder,TE
海胆卵裂球的第四次分裂：等量和不等量细胞分裂中的微管模式和肌球蛋白定位。
影响因子：
2.7
作者：
Schroeder,TE
通讯作者：
Schroeder,TE
影响因子：
56.9
作者：
DELOZANNE, A;SPUDICH, JA
通讯作者：
SPUDICH, JA