THYROID CANCER OCCURRING AS A LATE CONSEQUENCE OF HEAD-AND-NECK IRRADIATION
THYROID CANCER OCCURRING AS A LATE CONSEQUENCE OF HEAD-AND-NECK IRRADIATION
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DOI：
10.1056/nejm197605062941901
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发表时间：
1976-01-01
影响因子：
158.5
通讯作者：
FROHMAN, LA
中科院分区：
文献类型：
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作者：
FAVUS, MJ;SCHNEIDER, AB;FROHMAN, LA
1月1日至9月1日1974年3月30日，对1940年S和1950年S期间因上呼吸道感染和炎症性疾病接受放射治疗的5266人中的1056人(20.1%)进行了检查。扁桃体和鼻咽区是85%的受检者的治疗部位。可触及的结节性甲状腺病变占16.5%，99mTc高铁酸盐甲状腺显像检出未触及的病变占10.7%，结节病变患病率为27.2%。结节病变者71%手术发现甲状腺癌占33%(60/182)。对潜在危险因素的初步分析表明，辐射暴露与甲状腺结节的存在之间存在相关性(P<；0.001)。这些发现表明，在暴露的受试者中，结节性甲状腺疾病，无论是良性的还是恶性的，至少在35年内仍然是一个主要的健康问题。
From Jan. 1-Sept. 30, 1974, 1056 of 5266 subjects (20.1%) who received therapeutic irradiation for infections and inflammatory disease of the upper respiratory tract during the 1940''s and 1950''s were examined. The tonsillar and nasopharyngeal region was the treatment site in 85% of those examined. Palpable nodular thyroid disease was found in 16.5%, and nonpalpable lesions were detected by 99mTc pertechnetate thyroid imaging in an additional 10.7%, for a prevalence of nodular disease of 27.2%. Operation on 71% with nodular disease revealed thyroid cancer in 33% (60 of 182). Preliminary analysis for potential risk factors suggests a correlation between radiation exposure and the presence of thyroid nodules (P < 0.001). These findings indicate that nodular thyroid disease, benign and malignant, continues as a major health problem for at least 35 yr in exposed subjects.