Fiber‐type dependence of stretch‐induced force enhancement in rat skeletal muscle
Fiber‐type dependence of stretch‐induced force enhancement in rat skeletal muscle
复制标题
大鼠骨骼肌拉伸诱导力增强的纤维类型依赖性
作者：
K. Ramsey;A. Bakker;G. Pinniger
当活动肌肉被拉伸时，由于收缩和非收缩蛋白质的应变，力增加。我们研究了这种力量增强大鼠趾长伸肌（EDL）和比目鱼肌，不同的这些蛋白质的组成，以及它们对损伤的敏感性。在等长收缩过程中以不同的速度施加小的拉伸，从中我们量化了速度依赖性收缩和速度无关性非收缩对力增强的贡献。尽管比目鱼肌的收缩贡献显著大于EDL，但EDL的非收缩力增强显著大于比目鱼肌，并且在损伤离心收缩后增加了1.6倍。增加的收缩刚度可能在功能上有益于慢肌，因为对延长的阻力是维持姿势的基础。在牵张诱导的肌肉损伤后，这种能力受到损害，导致非收缩性蛋白质的应变增加，这可能有助于激活参与肌肉适应损伤的信号通路。肌肉神经42：769-777，2010
When an active muscle is stretched, the force increases due to strain of contractile and noncontractile proteins. We examined this force enhancement in rat extensor digitorum longus (EDL) and soleus muscles, which differ in their composition of these proteins, and their susceptibility to damage. Small stretches were applied at different velocities during isometric contractions from which we quantified the velocity‐dependent contractile and velocity‐independent noncontractile contributions to force enhancement. Whereas the contractile contribution was significantly greater in soleus than EDL, the noncontractile force enhancement was significantly greater in EDL than soleus, and increased ≈6‐fold after damaging eccentric contractions. The increased contractile stiffness may be functionally beneficial in slow muscle, as resistance to lengthening is fundamental to maintaining posture. Following stretch‐induced muscle damage this capacity is compromised, leading to increased strain of noncontractile proteins that may facilitate the activation of signaling pathways involved in muscle adaptation to injury. Muscle Nerve 42: 769–777, 2010
猫小腿三头肌的类型鉴定化学剥皮肌纤维的短程刚度与屈服之间的关系。
DOI：
10.1152/jn.1996.76.4.2280
发表时间：
1996
期刊：
Journal of neurophysiology.
影响因子：
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作者：
Malamud,JG;Godt,RE;Nichols,TR
通讯作者：
Nichols,TR