A New Potential Therapeutic Target for Cancer in Ubiquitin-Like Proteins-UBL3.
A New Potential Therapeutic Target for Cancer in Ubiquitin-Like Proteins-UBL3.
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DOI：
10.3390/ijms24021231
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发表时间：
2023-01-08
影响因子：
5.6
通讯作者：
Setou, Mitsutoshi
中科院分区：
文献类型：
--
作者：
Zhang, Hengsen;Chen, Bin;Waliullah, A. S. M.;Aramaki, Shuhei;Ping, Yashuang;Takanashi, Yusuke;Zhang, Chi;Zhai, Qing;Yan, Jing;Oyama, Soho;Kahyo, Tomoaki;Setou, Mitsutoshi
泛素样蛋白（Ubiquitin-like proteins，Ubls）通过对蛋白质的修饰参与多种生物学过程。Ubl修饰的失调与各种疾病，特别是癌症相关。泛素样蛋白3（Ubiquitin-like protein 3，UBL 3）是Ubl的一种，在小细胞外囊泡（small extracellular vesicle，sEV）蛋白分选和主要组织相容性复合物II类泛素化过程中起关键作用。已发现多种影响癌症特性的sEV蛋白与UBL 3相互作用。越来越多的研究表明，UBL 3表达影响癌细胞生长和癌症预后。在这篇综述中，我们提供了各种Ubls和癌症之间的关系的概述。本文主要介绍了UBL 3及其功能，总结了UBL 3的研究现状，并探讨了其作为肿瘤治疗靶点的潜力。
Ubiquitin-like proteins (Ubls) are involved in a variety of biological processes through the modification of proteins. Dysregulation of Ubl modifications is associated with various diseases, especially cancer. Ubiquitin-like protein 3 (UBL3), a type of Ubl, was revealed to be a key factor in the process of small extracellular vesicle (sEV) protein sorting and major histocompatibility complex class II ubiquitination. A variety of sEV proteins that affects cancer properties has been found to interact with UBL3. An increasing number of studies has implied that UBL3 expression affects cancer cell growth and cancer prognosis. In this review, we provide an overview of the relationship between various Ubls and cancers. We mainly introduce UBL3 and its functions and summarize the current findings of UBL3 and examine its potential as a therapeutic target in cancers.
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