Influence of various mixtures of inhaled toluene and xylene on the biological monitoring of exposure to these solvents in rats.
Influence of various mixtures of inhaled toluene and xylene on the biological monitoring of exposure to these solvents in rats.
复制标题
吸入甲苯和二甲苯的各种混合物对大鼠暴露于这些溶剂的生物监测的影响。
DOI：
10.1139/y92-048
复制
发表时间：
1992
影响因子：
2.1
通讯作者：
J. Brodeur
中科院分区：
文献类型：
--
作者：
R. Tardif;G. Plaa;J. Brodeur
本研究旨在描述同时吸入甲苯和二甲苯对其各自代谢处置某些方面的影响。成年雄性大鼠急性（5小时）暴露于75、150和225 ppm的甲苯或二甲苯以及这些溶剂的各种混合物：甲苯（75 ppm）和二甲苯（225 ppm）、甲苯（150 ppm）和二甲苯（150 ppm）、甲苯（225 ppm）和二甲苯（75 ppm）。与单次暴露相比，同时暴露导致 24 小时内尿液中马尿酸 (20-30%) 和甲基马尿酸 (4-40%) 的排泄量较低，尽管仅甲苯 (150 ppm) 和二甲苯 (150 ppm) 组合存在显着差异。此外，在接触后不久，血液中（甲苯，230％；二甲苯，500％）和脑中（甲苯，230％；二甲苯，320％）中的溶剂浓度增加。同时暴露还增强了两种溶剂的肺部消除（甲苯，190-240%；二甲苯，340-650%）。研究了重复同时暴露（9 天）对甲苯（150 ppm）和二甲苯（150 ppm）组合的影响，并将结果与重复暴露于单独施用的每种溶剂的结果进行比较。在这些条件下，重复同时暴露会减少尿代谢物的排泄，但仅在第一次暴露后发生。另一方面，在整个 9 天的暴露期间，同时暴露导致血液中甲苯 (210%) 和二甲苯 (240%) 的浓度显着升高。这些结果强烈表明甲苯和二甲苯之间存在相互代谢相互作用（抑制），影响两种溶剂的代谢处置，并最终影响大鼠暴露于溶剂组合的数据的生物监测。
The present study was undertaken to describe the influence of simultaneous exposure by inhalation to toluene and xylene on some aspects of their respective metabolic disposition. Adult male rats were exposed acutely (5 h) to 75, 150, and 225 ppm of toluene or xylene and to various mixtures of these solvents: toluene (75 ppm) and xylene (225 ppm), toluene (150 ppm) and xylene (150 ppm), toluene (225 ppm) and xylene (75 ppm). Compared with single exposure, simultaneous exposure resulted in lower amounts of excreted hippuric acid (20-30%) and methylhippuric acids (4-40%) in urine over a period of 24 h, even though significant differences were seen only with the toluene (150 ppm) and xylene (150 ppm) combination. In addition, increased concentrations of solvents in blood (toluene, 230%; xylene, 500%) and in brain (toluene, 230%; xylene, 320%) were found during the immediate post-exposure period. Simultaneous exposure also enhanced the pulmonary elimination of both solvents (toluene, 190-240%; xylene, 340-650%). Influence of repeated simultaneous exposure (9 days) was investigated for the toluene (150 ppm) and xylene (150 ppm) combination and the results compared with those of repeated exposure to each solvent administered singly. Under these conditions, repeated simultaneous exposure decreased the excretion of urinary metabolites, but only after the first exposure. On the other hand, simultaneous exposure resulted in significantly higher concentrations of toluene (210%) and xylene (240%) in blood throughout the entire 9-day exposure period. These results strongly suggest mutual metabolic interactions (inhibition) between toluene and xylene that affect the metabolic disposition of both solvents and ultimately the biological monitoring of data of exposure to a combination of solvents in rats.