Succinate: A Novel Mediator to Promote Atherosclerotic Lesion Progression
Succinate: A Novel Mediator to Promote Atherosclerotic Lesion Progression
复制标题
琥珀酸：促进动脉粥样硬化病变进展的新型介质
DOI：
10.1089/dna.2021.0345
复制
发表时间：
2022
影响因子：
3.1
通讯作者：
Dangheng Wei
中科院分区：
文献类型：
--
作者：
Shulei Zhang;Yamin Liang;Lu Li;Yanmei Chen;Peng Wu;Dangheng Wei
琥珀酸是线粒体能量代谢的重要中间产物。最近的研究表明，除了已知的传统代谢功能外，琥珀酸还在信号转导、免疫、炎症和翻译后修饰等方面发挥着重要作用。最近的研究表明，患有心血管疾病的患者和小鼠模型都有较高水平的血清琥珀酸和琥珀酸积累。动脉粥样硬化(AS)是冠心病、脑梗塞、周围血管疾病等心血管和外周血管疾病的病理基础，是影响人类健康的主要因素。本文就琥珀酸在AS疾病中的研究进展及其机制作一综述。
Succinate is an important intermediate product of mitochondrial energy metabolism. Recent studies revealed that beyond its known traditional metabolic functions, succinate plays important roles in signal transduction, immunity, inflammation, and posttranslational modification. Recent studies showed that patients and mouse models with cardiovascular disease have high levels of serum succinate and succinate accumulation. Atherosclerosis (As) is the pathological basis of cardiovascular and peripheral vascular diseases, such as coronary heart disease, cerebral infarction, and peripheral vascular disease, and is a major factor affecting human health. This article reviews the progression of succinate in As diseases and its underlying mechanisms.