THE EFFECT OF BODY-FAT DISTRIBUTION ON PULMONARY-FUNCTION TESTS
THE EFFECT OF BODY-FAT DISTRIBUTION ON PULMONARY-FUNCTION TESTS
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DOI：
10.1378/chest.107.5.1298
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发表时间：
1995-05-01
期刊：
影响因子：
9.6
通讯作者：
PEIRIS, AN
中科院分区：
文献类型：
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作者：
COLLINS, LC;HOBERTY, PD;PEIRIS, AN
虽然肥胖对肺功能测试的影响已被研究，但体脂分布的作用受到的关注有限。对上半身肥胖患者的肺部研究表明，他们的肺容量比下半身肥胖的肥胖患者更严重。我们检查了42名健康但正常或轻度肥胖的男性，以确定体脂分布是否影响肺功能测试。多项肥胖测量结果显示，肺活量测定和静态肺容量呈显著负相关，然而，与其他人体测量测量相比，二头肌皮褶厚度与总肺容量（TLC）具有最强的负相关性。腰臀比（WHR）表现出显着的负相关关系，只有当控制吸烟的静态肺容量。然而，比较WHR小于0.950的患者之间的肺功能测试，（下半身脂肪分布）和WHR ≥ 0.950的受试者（上半身脂肪分布）显示，上半身脂肪分布的患者FVC、FEV（1）和TLC显著降低，使用所有人体测量变量和年龄进行逐步多元回归分析，生成预测方程，其中包括残余容量（RV）和TLC的二头肌皮褶厚度。这表明，在正常和轻度肥胖男性中，上身脂肪分布可能与肺容量的适度损害有关。直到这项研究的结果可以应用到一个更大的，种族和人体测量多样化的人群，并对妇女，我们认为谨慎是必要的，当标准方程用于预测肺功能测试在人体测量多样化的人群。
Although the influence of obesity on pulmonary function tests has been examined, the role of body fat distribution has received limited attention. Pulmonary studies of patients severely affected by upper body obesity suggest they have more severely compromised lung volumes than obese patients with lower body obesity, We examined 42 healthy but normal or mildly obese men to determine if body fat distribution influences pulmonary function tests.Multiple measures of adiposity showed a significant inverse relationship with both spirometry and static lung volumes, However, the biceps skinfold thickness had the strongest inverse relationship with total lung capacity (TLC) compared to other anthropometric measures. The waist-to-hip ratio (WHR) demonstrated a significant inverse relationship with static lung volumes only when controlling for cigarette smoking. However, comparing pulmonary function tests between patients with a WHR less than 0.950 (lower body fat distribution) and subjects with a WHR of 0.950 or greater (upper body fat distribution) revealed that FVC, FEV(1), and TLC were significantly lower in the patients with upper body fat distribution, Stepwise multiple regression analysis was done using all anthropometric variables and age which generated predictive equations that included the biceps skinfold thickness for residual volume (RV) and TLC. This suggests that upper body fat distribution may be associated with a modest impairment of lung volumes in normal and mildly obese men. Until the findings of this study can be applied to a larger, ethnically and anthropometrically diverse population, and to women, we believe caution is warranted when standard equations are used to predict pulmonary function tests in an anthropometrically diverse population.