Serum antibodies in six-year-old children vaccinated in infancy with a Haemophilus influenzae type b-tetanus toxoid conjugate vaccine.
Serum antibodies in six-year-old children vaccinated in infancy with a Haemophilus influenzae type b-tetanus toxoid conjugate vaccine.
复制标题
婴儿期接种 b 型流感嗜血杆菌-破伤风类毒素结合疫苗的 6 岁儿童的血清抗体。
DOI：
10.1097/00006454-199602000-00016
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Robbins,JB
中科院分区：
文献类型：
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作者：
Claesson,BA;Trollfors,B;Anderson,PW;Johansson,J;Taranger,J;Schneerson,R;Robbins,JB
针对B型流感嗜血杆菌（HiB）的结合疫苗的对照试验已证明在预防儿童侵袭性HiB疾病方面具有很高的疗效。这种保护作用是通过疫苗诱导的抗Hib荚膜多糖（CPS）的血清抗体介导的。1-3目前尚不清楚疫苗诱导的血清抗体保持在保护水平以上多久，以及一般Hib疫苗接种将如何影响Hib疾病的长期流行病学。本研究的目的是检查瑞典儿童在6岁时血清抗Hib抗体的持续性，这些儿童在3岁时接种了Hib-破伤风类毒素结合疫苗（Hib-TT），5和12个月的年龄，并比较接种疫苗和未接种疫苗的6岁儿童的Hib抗体浓度。
Controlled trials with conjugate vaccines against Haemophilus influenzae type b (Hib) have demonstrated a high efficacy in preventing invasive Hib disease in children. The protection is mediated through vaccine-induced serum antibodies against the capsular polysaccharide (CPS) of Hib. 1-3 It is not yet known for how long vaccine-induced serum antibodies remain above protective levels and how general Hib vaccination will affect the epidemiology of Hib disease in the long run.The aims of this study were to examine the persistence of serum antibodies against Hib at the age of 6 years in Swedish children who had been vaccinated with a Hib-tetanus toxoid conjugate vaccine (Hib-TT) at 3, 5 and 12 months of age and to compare Hib antibody concentrations in vaccinated and unvaccinated 6-year-old children.