Depression predicts cognitive and functional decline one month after coronary artery bypass graft surgery (Neuropsychiatric Outcomes After Heart Surgery study).
Depression predicts cognitive and functional decline one month after coronary artery bypass graft surgery (Neuropsychiatric Outcomes After Heart Surgery study).
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冠状动脉旁路移植术后一个月抑郁可预测认知和功能下降（心脏手术后神经精神预后研究）
DOI：
10.1002/gps.5443
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发表时间：
2021-03
影响因子：
4
通讯作者：
Lee, Hochang B.
中科院分区：
文献类型：
--
作者：
Oldham, Mark A.;Lin, I-Hsin;Hawkins, Keith A.;Li, Fang-Yong;Yuh, David D.;Lee, Hochang B.
先前关于冠状动脉旁路移植术（CABG）术后认知和功能结果的研究主要独立地探索了这两个领域。在这项研究中，我们评估基线抑郁和认知作为冠状动脉搭桥手术后一个月临床痴呆评分总和（CDR-SB）下降的危险因素，这是认知和功能的综合衡量标准。心脏手术后神经精神结果 (NOAHS) 研究是一项前瞻性观察队列研究。三级护理学术中心。在 148 名接受 CABG 手术的患者的总研究样本中，124 名 (83.8%) 完成了一个月的随访评估。平均年龄为 66.3 岁，其中 32 名女性（25.8%），112 名白人（90.3%）。通过半结构化临床访谈评估认知、功能和抑郁症。使用 CDR-SB 定义认知和功能状态；轻度或重度抑郁症由汉密尔顿抑郁量表定义。此外，在基线时进行了神经心理学电池测试。 18 名受试者 (14.5%) 发生 CDR-SB 下降。单变量分析显示，年龄较大、抑郁、基线 CDR-SB 和术后谵妄与 1 个月下降相关。多元回归中，年龄较大（OR 1.1 [1.0–1.2]）和抑郁症（OR 6.2 [1.1–35.0]）仍然显着。在单独的模型中，视觉韦克斯勒记忆量表（延迟）、霍普金斯言语学习测试（立即和延迟）、受控口语流畅性测试和 Trails B 的基线表现预测 CDR-SB 下降。大约七分之一的患者在 CABG 手术后一个月出现 CDR-SB 下降。此外，术前抑郁症值得认可，因为它是 CABG 后一个月 CDR-SB 下降的预测因子。
Prior research on cognitive and functional outcomes after coronary artery bypass graft (CABG) surgery has largely explored these two domains in isolation. In this study, we assess baseline depression and cognition as risk factors for decline in the Clinical Dementia Rating Sum-of-Boxes (CDR-SB) one month post-CABG surgery, which a combined measure of cognition and function. The Neuropsychiatric Outcomes After Heart Surgery (NOAHS) study is a prospective observational cohort study. A tertiary care, academic center. Of a total study sample of 148 patients undergoing CABG surgery, 124 (83.8%) completed one-month follow-up assessment. Mean age was 66.3, 32 (25.8%) female, and 112 (90.3%) White. Cognition, function and depression were assessed on semi-structured clinical interviews. Cognitive and functional status were defined using CDR-SB; mild or major depression was defined by the Hamilton Depression Rating Scale. Additionally, neuropsychological battery was performed at baseline. CDR-SB decline occurred in 18 (14.5%) subjects. Older age, depression, baseline CDR-SB, and postoperative delirium were associated with one-month decline on univariate analysis. Older age (OR 1.1 [1.0–1.2]) and depression (OR 6.2 [1.1–35.0]) remained significant on multivariate regression. In separate models, baseline performance on visual Wechsler memory scale (delayed), Hopkins verbal learning test (immediate and delayed), controlled oral word fluency test, and Trails B predicted CDR-SB decline. Roughly one in seven patients experienced CDR-SB decline one month after CABG surgery. Also, preoperative depression deserves recognition for being a predictor of CDR-SB decline one month post-CABG.
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DOI：
10.1007/s12630-012-9675-y
发表时间：
2012-05-01
影响因子：
4.2
作者：
Djaiani, George;Katznelson, Rita;Karski, Jacek
通讯作者：
Karski, Jacek
影响因子：
4
作者：
Taragano, Fernando E.;Allegri, Ricardo F.;Dillon, Carol
通讯作者：
Dillon, Carol
影响因子：
--
作者：
Morris, JC;Storandt, M;Berg, L
通讯作者：
Berg, L
影响因子：
8.8
作者：
Evered, L.;Silbert, B.;Eckenhoff, R. G.
通讯作者：
Eckenhoff, R. G.
影响因子：
1.3
作者：
Uymaz, Baris;Sezer, Gul;Aybek, Tayfun
通讯作者：
Aybek, Tayfun