Relationship of Low-Circulating "Anti-Aging'' Klotho Hormone with Disability in Activities of Daily Living among Older Community-Dwelling Adults
Relationship of Low-Circulating "Anti-Aging'' Klotho Hormone with Disability in Activities of Daily Living among Older Community-Dwelling Adults
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DOI：
10.1089/rej.2011.1268
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发表时间：
2012-06-01
影响因子：
2.6
通讯作者：
Ferrucci, Luigi
中科院分区：
文献类型：
--
作者：
Crasto, Candace L.;Semba, Richard D.;Ferrucci, Luigi
衰老抑制基因 klotho 编码一种单次跨膜蛋白 klotho，在小鼠中，当该蛋白过度表达时，其寿命会延长；而当表达被破坏时，该蛋白会加速衰老，导致骨骼肌萎缩和骨矿物质密度降低。我们试图研究血浆克洛托与社区老年人日常生活活动（ADL）障碍之间的关系。在一项横断面研究中，对 802 名 65 岁成年人的人群样本中的血浆 klotho 进行了测量，这些成年人参加了意大利托斯卡纳的“Invecchiare in Chianti”（基安蒂地区的老龄化）(InCHIANTI) 研究。患有 ADL 障碍的成年人的总体比例为 11.9%。平均（标准偏差）klotho 浓度为 689 (238) 皮克/毫升。从血浆 klotho 的最低三分位数到最高三分位数，分别有 16.1%、9.7% 和 5.6% 的参与者患有 ADL 障碍 (p = 0.0004)。在多变量中，血浆 klotho 每增加 1 个标准差，与 ADL 障碍相关（比值比 = 0.57，95% 置信区间 0.35-0.93，p = 0.02） 逻辑回归模型调整了年龄、教育、认知、身体活动、身体表现、总胆固醇、酒精和烟草使用以及慢性疾病。低血浆 klotho 浓度与老年社区居住男性和女性的 ADL 残疾独立相关。
The aging suppressor gene klotho encodes a single-pass transmembrane protein klotho that in mice is known to extend life span when overexpressed and to resemble accelerated aging, with skeletal muscle atrophy and decreased bone mineral density, when expression is disrupted. We sought to examine the relationship between plasma klotho and disability in activities of daily living (ADL) in older community-dwelling adults. In a cross-sectional study, plasma klotho was measured in a population-based sample of 802 adults, 65 years, who participated in the "Invecchiare in Chianti'' (Aging in the Chianti Area) (InCHIANTI) study in Tuscany, Italy. The overall proportion of adults with ADL disability was 11.9%. Mean (standard deviation) klotho concentrations were 689 (238) pg/mL. From the lowest to the highest tertile of plasma klotho, 16.1%, 9.7%, and 5.6% of participants, respectively, had ADL disability (p = 0.0004). Plasma klotho, per 1 standard deviation increase, was associated with ADL disability (odds ratio = 0.57, 95% confidence interval 0.35-0.93, p = 0.02) in a multivariate logistic regression model adjusting for age, education, cognition, physical activity, physical performance, total cholesterol, alcohol and tobacco use, and chronic diseases. Low plasma klotho concentrations were independently associated with ADL disability among older community-dwelling men and women.