Thomsen-Friedenreich and its precursor (Tn) antigen expression in normal skin and in benign cutaneous tumours: a marker for sebaceous differentiation.
Thomsen-Friedenreich and its precursor (Tn) antigen expression in normal skin and in benign cutaneous tumours: a marker for sebaceous differentiation.
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Thomsen-Friedenreich 及其前体 (Tn) 抗原在正常皮肤和良性皮肤肿瘤中的表达：皮脂分化的标志物。
作者：
Jean Kanitakis;I. al;M. Faure;A. Claudy
T抗原是癌症相关碳水化合物的核心二糖，其表达据称与某些癌症的预后相关。我们研究了表达的T抗原及其前体（Tn）与单克隆抗体在福尔马林固定标本的正常皮肤和各种良性皮肤肿瘤和炎性病变（n：105）。在正常皮肤中，这两种抗原始终表达在成熟皮脂腺细胞的细胞质内，很少在分泌性汗腺细胞的管腔表面。所有（21/21）皮脂腺肿瘤显示强T/Tn阳性;几个（9/16）汗腺肿瘤也免疫反应，但更弱。皮拉尔（n = 11）、非附件肿瘤（n = 45）和炎性病变（n = 12）通常无反应。这些结果表明，T抗原是一个敏感的标志物皮脂腺分化，可用于附件皮肤肿瘤的研究，在常规处理的组织标本。
The Thomsen-Friedenreich (T) antigen is the core disaccharide of cancer-associated carbohydrates, whose expression allegedly correlates with the prognosis of some carcinomas. We studied the expression of the T antigen and its precursor (Tn) with monoclonal antibodies in formalin-fixed specimens of normal skin and various benign cutaneous tumours and inflammatory lesions (n: 105). In normal skin, both antigens were consistently expressed within the cytoplasm of mature sebocytes and rarely over the luminal surface of secretory sweat gland cells. All (21/21) sebaceous tumours showed strong T/Tn positivity; several (9/16) sweat-gland tumours were also immunoreactive, although more weakly. Pilar (n = 11), non-adnexal tumours (n = 45) and inflammatory lesions (n = 12) were as a rule unreactive. These results suggest that the T antigen is a sensitive marker of sebaceous differentiation that can be used for the study of adnexal skin tumours in routinely processed tissue specimens.