Effects of thyroid state on preference for and sensitivity to ethanol in Fischer-344 rats.
Effects of thyroid state on preference for and sensitivity to ethanol in Fischer-344 rats.
复制标题
甲状腺状态对 Fischer-344 大鼠对乙醇的偏好和敏感性的影响。
DOI：
10.1016/0278-5846(93)90080-c
复制
发表时间：
1993
影响因子：
5.6
通讯作者：
Mason,GA
中科院分区：
文献类型：
--
作者：
Noonan,LR;Walker,CH;Li,L;Garbutt,JC;PrangeJr,AJ;Mason,GA
1.1.多个研究小组报告称，甲状腺状态可以改变大鼠对乙醇的偏好。但不同方法、不同品系大鼠的结果并不一致。 2.2．在这项研究中，甲状腺切除术或T4增强术分别用于在成年雄性Fischer-344大鼠中产生甲状腺功能减退症或甲状腺功能亢进症。3.3．比较了甲状腺功能减退、甲状腺功能亢进和甲状腺功能正常大鼠对乙醇或自来水弱溶液（4%或5%）的偏好以及乙醇诱导的镇静和低温的情况。4.4．三组之间的偏好指数（乙醇与总液体消耗的比率）没有观察到显着差异；然而，与甲状腺功能正常或甲状腺功能亢进的大鼠相比，乙醇在甲状腺功能减退大鼠摄入的总热量中所占的比例更大。5.5．单次 i.p. 产生的睡眠持续时间与甲状腺功能正常的对照组相比，注射 2.5 mg/kg 乙醇在甲状腺功能亢进大鼠中增加（34%），在甲状腺功能减退大鼠中减少（16%）。只有甲亢的影响在0.05水平上才显着。6.6．结肠温度随甲状腺状态不同而不同（甲状腺功能亢进>甲状腺功能正常>甲状腺功能减退），但乙醇产生的降低程度不因甲状腺状态而异。7.7．观察到的乙醇诱导镇静的差异与大脑 TRH 水平的差异以及对与不同甲状腺状态相关的神经递质系统的影响一致。
1.1. It has been reported by several groups that thyroid status can alter ethanol preference in rats. However, results using different methods and different strains of rats have not been consistent.2.2. In this study, thyroidectomy or T4augmentation was used to produce hypothyroidism or hyperthyroidism, respectively, in adult male Fischer-344 rats.3.3. Preference for weak solutions (4 or 5%) of ethanol or tap water and ethanol-induced sedation and hypothermia were compared in hypothyroid, hyperthyroid and euthyroid rats.4.4. No significant differences in preference indices (the ratios of ethanol to total liquid consumed) among the three groups were observed; however, for ethanol to contribute a greater portion of total calories ingested by hypothyroid rats than by euthyroid or hyperthyroid rats.5.5. The duration of sleep resulting from a single i.p. injection of 2.5 mg/kg ethanol was increased (by 34%) in hyperthyroid rats and decreased (by 16%) in hypothyroid rats compared to euthyroid controls. Only the effect of hyperthyroidism was significant at the 0.05 level.6.6. Colonic temperatures differed with thyroid state (hyperthyroid>euthyroid>hypothyroid) but the decrease produced by ethanol did not differ by thyroid state.7.7. Observed differences in ethanol-induced sedation are consistent with differences in brain TRH levels and effects on neurotransmitter systems associated with different thyroid states.