Cadmium-induced renal dysfunction and mortality in two cohorts: Disappearance of the association in a generation born later
Cadmium-induced renal dysfunction and mortality in two cohorts: Disappearance of the association in a generation born later
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DOI：
10.1016/j.toxlet.2007.01.009
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发表时间：
2007-03-30
影响因子：
3.5
通讯作者：
Soda, Midori
中科院分区：
文献类型：
--
作者：
Arisawa, Kokichi;Uemura, Hirokazu;Soda, Midori
在两个队列中调查了环境镉暴露与死亡率之间的关系。研究人群包括分别于1982年和1992年参加过日本长崎县镉污染地区健康调查的275名（队列I）和329名（队列II）居民（年龄在bb0 = 40岁）。随访期从1982年或1992年延长到2005年。1980-1983年以来，由于镉污染稻田的恢复，研究区日粮镉摄入量有所下降。在队列I中，尿β 2-微胶质蛋白（β 2-MG）浓度为1000 μ g/g肌酐（cr.）的患者死亡率是区域参考率的1.41倍（95%可信区间[CI] 1.07-1.83）。在调整了年龄和其他变量后，在男性中，尿中n -乙酰- β - d -氨基葡萄糖苷酶，在女性中，血清肌酐、β 2-MG清除率和尿中β 2-MG与死亡率的增加显著相关。然而，在队列II中，尿β 2-MG或总蛋白与生存率无显著相关性。这些发现表明，镉诱发的肾功能障碍是死亡率的一个重要预测指标，但这种关联正在消失，可能是因为晚期病例的选择性消失以及暴露和身体负担的减少。2007爱思唯尔爱尔兰有限公司版权所有。
The association between exposure to environmental cadmium and mortality was investigated in two cohorts. The study population consisted of 275 (cohort I) and 329 (cohort II) residents (aged >= 40 years) in a cadmium-polluted area, Nagasaki Prefecture, Japan, who had participated in health surveys conducted in 1982 and 1992, respectively. The follow-up period extended from 1982 or 1992 to 2005. In the study area, the dietary cadmium intake had decreased after 1980-1983 because of the restoration of cadmium-polluted paddy fields. In cohort I, the mortality rate among those with urinary beta 2-microglibulin (beta 2-MG) concentration > 1000 mu g/g creatinine (cr.) was 1.41 times higher than the regional reference rate (95% confidence interval [CI] 1.07-1.83). After adjusting for age and other variables, in men, urinary N-acetyl-beta-D-glucosaminidase, and in women, serum creatinine, beta 2-MG clearance, and urinary beta 2-MG were significantly associated with increased mortality. However, in cohort II, urinary beta 2-MG or total protein was not significantly associated with survival. These findings indicate that cadmium-induced renal dysfunction was a significant predictor of mortality, but that such an association is disappearing, probably because of the selective loss of advanced cases and reduced exposure and body burden. (C) 2007 Elsevier Ireland Ltd. All rights reserved.