Acute length adaptation and adjustable preload in the human detrusor
Acute length adaptation and adjustable preload in the human detrusor
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DOI：
10.1002/nau.22820
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发表时间：
2016-09-01
影响因子：
2
通讯作者：
Klausner, Adam P.
中科院分区：
文献类型：
--
作者：
Colhoun, Andrew F.;Speich, John E.;Klausner, Adam P.
目的在动物模型中研究逼尿肌的长度适应性和可调前负荷的生物力学特性。本体外研究旨在证明人逼尿肌平滑肌具有长度适应性和可调节的前负荷张力，这可能在膀胱过度活动症和逼尿肌活动不足中起重要作用。将人逼尿肌平滑肌条拉伸和收缩超过最佳长度，然后在先前的最佳长度收缩三次，以确定是否可以重新获得最大有效张力。确立了习为了证明可调节的前负荷（T-ap），使人逼尿肌平滑肌条经受预定义的加载-卸载（应变软化）序列以减少前负荷。然后，组织收缩和重复的序列，以确定是否这个积极的过程恢复preload.ResultsNine患者（平均年龄，62）提供组织：89%的男性尿路上皮癌和少数（22%）也有神经源性膀胱功能障碍。在长度适应方案中，收缩显示主动张力的进行性增加（P
AimsThe biomechanical properties of length adaptation and adjustable preload have been previously identified in detrusor smooth muscle in animal models. This in vitro study aims to show that human detrusor smooth muscle exhibits length adaptation and adjustable preload tension which could play an important role in both overactive bladder and detrusor underactivity.MethodsIn order to demonstrate length adaptation, human detrusor smooth muscle strips are stretched and contracted beyond an optimum length and then contracted three times at the previous optimum length to determine if maximum active tension could be re-established. To demonstrate adjustable preload (T-ap), human detrusor smooth muscle strips are subjected to a pre-defined loading-unloading (strain softening) sequence to reduce preload. Then, tissues are contracted and the sequence is repeated to determine if this active process restored preload.ResultsNine patients (average age, 62) provide tissue: 89% are men with urothelial carcinoma and a minority (22%) also have neurogenic bladder dysfunction. In the length adaptation protocol, contractions show progressive increases in active tension (P