Ependymoma with neuropil-like islands: a case report with diagnostic and histogenetic implications
Ependymoma with neuropil-like islands: a case report with diagnostic and histogenetic implications
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DOI：
10.1007/s00401-004-0927-y
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发表时间：
2005-02-01
影响因子：
12.7
通讯作者：
Giangaspero, F
中科院分区：
文献类型：
--
作者：
Gessi, M;Marani, C;Giangaspero, F
我们报告一例室管膜瘤的神经元分化形式的神经丸样岛。一名6岁男孩因头痛和呕吐的短暂病史接受临床检查。脑部电脑断层显示一个大的，部分囊性的，顶骨到枕骨的病变。肿瘤由胶质原纤维酸性蛋白阳性的圆形细胞组成，呈血管周围排列，散在的神经丸样岛状，突触素呈强烈阳性。尽管放疗，肿瘤复发，表现出明显的发育不全特征，但缺乏神经丸样岛。根据不同谱系的胶质瘤中偶尔会发生神经元分化而不影响预期的生物学行为的概念，讨论了肿瘤的组织学特征。
We describe a case of ependymoma with neuronal differentiation in form of neuropil-like islands. A 6-year-old boy presented at clinical examination for a short history of headaches and vomiting. Brain computed tomography showed a large, partially cystic, parieto-occipital lesion. The tumor was composed by glial fibrillary acidic protein-positive round cells with a perivascular arrangement and scattered neuropil-like islands, showing intense positivity for synaptophysin. Despite radiotherapy, the tumor recurred, showing frank features of anaplasia, but lacking the neuropil-like islands. The histological features of the tumor are discussed in the light of the concept that neuronal differentiation can occur occasionally in gliomas of different lineage without affecting the expected biological behavior.