PHOSPHOLIPASE A(2) REGULATES CRITICAL INFLAMMATORY MEDIATORS OF MULTIPLE ORGAN FAILURE
PHOSPHOLIPASE A(2) REGULATES CRITICAL INFLAMMATORY MEDIATORS OF MULTIPLE ORGAN FAILURE
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DOI：
10.1006/jsre.1994.1032
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发表时间：
1994-02-01
影响因子：
2.2
通讯作者：
BANERJEE, A
中科院分区：
文献类型：
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作者：
ANDERSON, BO;MOORE, EE;BANERJEE, A
PLA2是一个调控类花生酸合成和PAF产生的调节酶家族。PLA2必须在细胞内受到严格调控，否则会导致细胞破坏。PLA2的循环释放发生在严重疾病状态，包括败血症、休克、严重损伤和胰腺炎，所有这些都与ARDS和MOF的发展有关。实验和临床证据表明，PLA2可能在这些炎症性疾病的发展中起主要的调节作用。这一证据表明，PLA2激活抑制剂可能在未来的重症监护管理中发挥重要作用。
PLA2 is a family of regulatory enzymes that control eicosanoid synthesis and PAF production. PLA2 must be tightly regulated within the cell or cell destruction results. Circulatory release of PLA2 occurs in states of profound illness including sepsis, shock, severe injury, and pancreatitis, all of which are linked to the development of ARDS and MOF. Experimental and clinical evidence suggests that PLA2 may serve a primary regulatory role in the development of these inflammatory disorders. This evidence suggests that inhibitors of PLA2 activation could play an important role in future intensive care management.