Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: Observations from 160,000 patients
Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: Observations from 160,000 patients
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DOI：
10.1016/j.plefa.2012.12.004
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发表时间：
2013-04-01
影响因子：
3
通讯作者：
McConnell, Joseph P.
中科院分区：
文献类型：
--
作者：
Harris, William S.;Pottala, James V.;McConnell, Joseph P.
背景资料：据报道，红细胞（RBC）的脂肪酸（FA）组成可提供有关冠心病（CHD）风险的预后信息。特别是，Omega-3指数（RBC二十碳五烯酸+二十二碳六烯酸，EPA + DHA）已被证明与心脏性猝死和急性冠状动脉综合征的风险独立且负相关。较高的亚油酸（n-6）和较低的反式FA水平也与改善CHD结局相关。因此，红细胞FA面板最近已被引入到常规的临床实验室testing.Objective：本研究的目的是定义基于年龄和性别的规范RBC FA levels.Methods：RBC FA配置文件从约160,000例（48%的男性，52%的女性）在健康诊断实验室进行了测量。这些数据被用来创建年龄十年和性别的具体规范（性别）。FA值表示为总确定的FA.Results的百分比：与男性相比，女性一般有较高的C18反式水平，和10-29岁之间的年龄，他们有DHA和较低的EPA水平。在主要的脂肪酸类中，饱和脂肪（占总量的41%）和反式脂肪（约占0.85%）没有明显的年龄差异，而单不饱和脂肪往往略有上升。在两种主要的n-6多不饱和化合物，花生四烯酸和亚油酸中，前者在几十年内没有变化（16.4%丰度），而后者下降了约2个百分点（13.0-11.1%）。Omega-3指数的总体中位数为4.5%，几十年来增加了约1.5个百分点。结论：红细胞饱和脂肪酸、单不饱和脂肪酸和多不饱和脂肪酸水平在整个生命周期内基本稳定，但后者的组成发生了变化，欧米伽-3指数升高，亚油酸减少。年轻女性中较高的DHA和较低的EPA水平与生育早期EPA向DHA转化的增强一致。RBC FA标准的可用性将有助于研究FA状态改变与人类疾病之间的关系，并将帮助医生评估患者的n-3 FA状态。(c)2013爱思唯尔有限公司保留所有权利。
Background: The fatty acid (FA) composition of the red blood cell (RBC) has been reported to provide prognostic information regarding risk for coronary heart disease (CHD). In particular, the Omega-3 Index (RBC eicosapentaenoic acid + docosahexaenoic acid, EPA + DHA) has been shown to be independently and inversely related to risk for sudden cardiac death and for acute coronary syndromes. Higher linoleic acid (n-6) and lower trans FA levels have also been associated with improved CHD outcomes. Accordingly, the RBC FA panel has recently been introduced in routine clinical laboratory testing.Objective: The purpose of this study was to define age- and gender-based norms for RBC FA levels.Methods: RBC FA profiles from about 160,000 patients (48% from males, 52% from females) were measured at Health Diagnostic Laboratory. These data were used to create age decade and gender-specific norms (percentiles). FA values were expressed as a percent of total identified FA.Results: Compared to men, women generally had higher C18 trans levels, and between the ages of 10-29 years, they had DHA and lower EPA levels. Among the major FA classes, saturated (41% of total) and trans (similar to 0.85%) fats did not vary appreciably by age, whereas monounsaturated fats tended to rise slightly. Of the two major n-6 polyunsaturates, arachidonic and linoleic acids, the former was unchanged across decades (16.4% abundance) whereas the latter decreased by about 2 percentage points (13.0-11.1%). The overall median Omega-3 Index was 4.5%, and across the decades it increased by about 1.5 percentage points. The Omega-3 Index and linoleic acid stabilized after age 70.Conclusion: Whereas RBC saturated, mono- and polyunsaturated FA levels are generally stable across the lifespan, there is a shift in the composition of the latter, with an increase in the omega-3 Index and a decrease in linoleic acid. Higher DHA and lower EPA levels in younger women is consistent with enhanced conversion of EPA to DHA during the early reproductive years. The availability of RBC FA norms will facilitate research into the relationships between altered FA status and human disease, and will help physicians evaluate the n-3 FA status of their patients. (c) 2013 Elsevier Ltd. All rights reserved.