Immunogenomics and systems biology of vaccines.
Immunogenomics and systems biology of vaccines.
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DOI：
10.1111/j.1600-065x.2010.00971.x
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发表时间：
2011-01
影响因子：
8.7
通讯作者：
Pulendran B
中科院分区：
文献类型：
--
作者：
Buonaguro L;Pulendran B
疫苗是预防或控制具有高发病率或高死亡率的传染病的有力工具。然而，尽管疫苗得到了广泛使用，但我们对疫苗有效激发保护性免疫反应的潜在机制仍了解有限。近期研究表明，这是先天性免疫系统和适应性免疫系统协同作用的结果。免疫是由一系列多层面的综合反应构成，涉及数千种分子的动态相互作用，其分子种类清单在不断更新，以填补这一谜题中的诸多空白。新技术和计算工具的近期发展使得能够对免疫的所有组成部分之间随时间推移的相互作用进行全面且定量的分析。在此，我们综述了先天性免疫在宿主对疫苗抗原的反应中所起的作用，以及系统生物学在为疫苗作用机制提供相关且新颖的见解以改进疫苗设计和提高其有效性方面的潜力。
Vaccines represent a potent tool to prevent or contain infectious diseases with high morbidity or mortality. However, despite their widespread use, we still have a limited understanding of the mechanisms underlying the effective elicitation of protective immune responses by vaccines. Recent research suggests that this represents the cooperative action of the innate and adaptive immune systems. Immunity is made of a multifaceted set of integrated responses involving a dynamic interaction of thousands of molecules, whose list is constantly updated to fill the several empty spaces of this puzzle. The recent development of new technologies and computational tools permits the comprehensive and quantitative analysis of the interactions between all of the components of immunity over time. Here, we review the role of the innate immunity in the host response to vaccine antigens and the potential of systems biology in providing relevant and novel insights in the mechanisms of action of vaccines to improve their design and effectiveness.