A novel carotenoid biosynthetic route via oxidosqualene
A novel carotenoid biosynthetic route via oxidosqualene
复制标题
一种新的氧化角鲨烯类胡萝卜素生物合成途径
DOI：
10.1016/j.bbrc.2022.01.105
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发表时间：
2022
影响因子：
3.1
通讯作者：
Daisuke Umeno
中科院分区：
文献类型：
--
作者：
Yusuke Otani;Takashi Maoka;Shigeko Kawai-Noma;Kyoichi Saito;Daisuke Umeno
已知的800多个类胡萝卜素是由三个共轭双键的植烯或4，4‘-双菲烯(脱氢角鲨烯)合成的。本文报道了金黄色葡萄球菌和甲基单胞菌产生的类胡萝卜素脱饱和酶CrtN能接受植物或动物类三萜的前体氧化色谱烯，生成具有8、9或10个共轭双键的黄色类胡萝卜素色素。由此产生的途径是类胡萝卜素色素的第二条非自然途径和第一条未经植物烯生物合成的类胡萝卜素色素途径。
Over 800 known carotenoids are synthesized from phytoene or 4,4′-diapophytoene (dehydrosqualene) characterized by three conjugated double bonds. In this paper, we report that carotenoid desaturase CrtN fromStaphylococcus aureusandMethylomonascan accept oxidosqualene, which is the precursor for plant- or animal-type triterpenoids, yielding the yellow carotenoid pigments with 8, 9, or 10 conjugated double bonds. The resulting pathway is the second nonnatural route for carotenoid pigments and the first pathway for carotenoid pigments not biosynthesizedvia(diapo)phytoene.