Protein kinase C and cancer: what we know and what we do not.
Protein kinase C and cancer: what we know and what we do not.
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自上世纪70年代末S发现以来，蛋白激酶C(PKC)同工酶是目前研究最广泛的信号通路之一。PKCS通过多种途径传递信号，控制与细胞周期进程、肿瘤发生和转移转移相关的基因的表达。尽管关于细胞模型中控制PKC激活和功能的机制有大量的信息，但单个PKC同工酶在人类癌症进展中的相关性仍然存在争议。虽然PKC同工酶的表达在多种癌症类型中都有改变，但这种改变与疾病的发生和发展之间的因果关系仍不明确。在过去几年发展的动物模型有助于更好地了解个体PKC参与各种癌症类型以及在特定致癌改变的背景下。解开PKC同工酶影响肿瘤发生和转移机制的巨大复杂性，是重新评估其作为癌症治疗药理靶点的潜力的关键。
Since their discovery in the late 1970’s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumorigenesis and metastatic dissemination. Despite the vast amount of information concerning the mechanisms that control PKC activation and function in cellular models, the relevance of individual PKC isozymes in the progression of human cancer is still a matter of controversy. Although the expression of PKC isozymes is altered in multiple cancer types, the causal relationship between such changes and the initiation and progression of the disease remains poorly defined. Animal models developed in the last years helped to better understand the involvement of individual PKCs in various cancer types and in the context of specific oncogenic alterations. Unraveling the enormous complexity in the mechanisms by which PKC isozymes impact on tumorigenesis and metastasis is key for reassessing their potential as pharmacological targets for cancer treatment.
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