Cholinergic Augmentation Modulates Visual Task Performance in Sleep-Deprived Young Adults
Cholinergic Augmentation Modulates Visual Task Performance in Sleep-Deprived Young Adults
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DOI：
10.1523/jneurosci.4045-08.2008
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发表时间：
2008-10-29
影响因子：
5.3
通讯作者：
Chee, Michael W. L.
中科院分区：
文献类型：
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作者：
Chuah, Lisa Y. M.;Chee, Michael W. L.
通过24小时的完全睡眠剥夺来扰乱正常的认知功能，我们进行了一项双盲、安慰剂对照的交叉研究，以评估乙酰胆碱酯酶抑制剂多奈哌齐对28名健康的年轻成年志愿者的行为表现和任务相关的大脑激活的影响。行为任务包括参数化操作的视觉短期记忆负荷和知觉负荷在不同的实验中间接评价注意力。睡眠剥夺显著降低了所有水平的视觉记忆和知觉负荷的后皮层激活（顶叶内沟和层外皮层）。多奈哌齐根据睡眠剥夺后未经治疗的准确性是否下降来调节个人在这两项任务中的表现。关键的是，多奈哌齐诱导的后皮质区神经激活的增加与准确性的提高之间存在显著的相关性。因此，睡眠剥夺后视觉短期记忆的减少可能源于视觉注意力和/或视觉处理能力的下降。增强胆碱能可以缓解易受睡眠剥夺影响的个体的这些缺陷，但对那些抵抗睡眠剥夺的人可能有中性或负面影响。
Using 24 h of total sleep deprivation to perturb normal cognitive function, we conducted a double-blind, placebo-controlled crossover study to evaluate the effect of the acetylcholinesterase inhibitor, donepezil, on behavioral performance and task-related brain activation in 28 healthy, young, adult volunteers. The behavioral tasks involved the parametric manipulation of visual short-term memory load and perceptual load in separate experiments indirectly evaluating attention. Sleep deprivation significantly reduced posterior cortical activation (intraparietal sulcus and extrastriate cortex) at all levels of visual memory as well as perceptual load. Donepezil modulated an individual's performance in both tasks in accordance to whether accuracy declined after sleep deprivation without treatment. Critically, there were significant correlations between donepezil-induced increases in neural activation in the posterior cortical areas and improvement in accuracy. Reduced visual short-term memory after sleep deprivation may thus originate from a decline in visual attention and/or visual processing. Cholinergic augmentation can alleviate these deficits in individuals vulnerable to the effects of sleep deprivation, but it may have neutral or negative effects on those resistant to sleep deprivation.