Soluble Dectin-1 as a tool to detect β-glucans
Soluble Dectin-1 as a tool to detect β-glucans
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DOI：
10.1016/j.jim.2006.05.013
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发表时间：
2006-07-31
影响因子：
2.2
通讯作者：
Brown, Gordon D.
中科院分区：
文献类型：
--
作者：
Graham, Lisa M.;Tsoni, S. Vicky;Brown, Gordon D.
beta-Glucans are structural components of fungal cell walls which are involved in the immune recognition of fungal pathogens and possess beneficial immunomodulatory activities in isolated form. Here we have developed a soluble chimeric form of the major mammalian p-glucan receptor, Dectin-1, and demonstrate its application for the detection and characterisation of soluble and insoluble beta-glucans, including fungal particles, using ELISA, flow cytometric and fluorescence-based microscopy assays. (c) 2006 Elsevier B.V. All rights reserved.
