Age-related changes in reappraisal of appetitive cravings during adolescence.
Age-related changes in reappraisal of appetitive cravings during adolescence.
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DOI：
10.1016/j.neuroimage.2014.12.037
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发表时间：
2015-03
期刊：
影响因子：
5.7
通讯作者：
Pfeifer JH
中科院分区：
文献类型：
--
作者：
Giuliani NR;Pfeifer JH
调节诱惑和控制食欲的能力是青少年健康发展的一个重要方面，但这一过程背后的神经系统却研究不足。在本研究中，平均分布在10至23岁的60名健康女性使用重新评估来调节消费个人渴望和不渴望不健康食品的欲望。重新评价引发了常见的自我调节区域的活动，包括背侧和腹侧前额叶皮层（特别是上级和额下回），背侧前扣带回皮层和顶下小叶。观察个人渴望的食物（与不渴望的食物相比）引起了包括腹侧纹状体在内的区域的活动，以及更多的吻侧和腹侧前扣带皮层延伸到眶额皮层。年龄与右额下回的调节相关活动呈正相关，与右上级和背外侧前额叶皮层的反应相关活动呈负相关。调整后的BMI与主要位于左侧额叶和顶叶区域的调节相关活动呈负相关。这些结果表明，在重新评估消极情绪中看到的与年龄相关的变化在重新评估食物渴望中可能不那么明显。因此，重新评估对食物的渴望可能是一种有效的方法，可以教青少年管理对青春期遇到的其他诱惑的渴望，包括酒精，毒品和不健康的食物。
The ability to regulate temptation and manage appetitive cravings is an important aspect of healthy adolescent development, but the neural systems underlying this process are understudied. In the present study, 60 healthy females evenly distributed from 10 to 23 years of age used reappraisal to regulate the desire to consume personally-craved and not craved unhealthy foods. Reappraisal elicited activity in common self-regulation regions including dorsal and ventral lateral prefrontal cortex (specifically superior and inferior frontal gyri), dorsal anterior cingulate cortex, and inferior parietal lobule. Viewing personally-craved foods (versus not craved foods) elicited activity in regions including the ventral striatum, as well as more rostral and ventral anterior cingulate cortex extending into orbitofrontal cortex. Age positively correlated with regulation-related activity in the right inferior frontal gyrus, and negatively correlated with reactivity-related activity in the right superior and dorsolateral prefrontal cortices. Age-adjusted BMI negatively correlated with regulation-related activity in predominantly left lateralized frontal and parietal regions. These results suggest that the age-related changes seen in the reappraisal of negative emotion may not be as pronounced in the reappraisal of food craving. Therefore, reappraisal of food craving in particular may be an effective way to teach teenagers to manage cravings for other temptations encountered in adolescence, including alcohol, drugs, and unhealthy food.