Molecular and epidemiologic trends of caliciviruses associated with outbreaks of acute gastroenteritis in the United States, 2000-2004
Molecular and epidemiologic trends of caliciviruses associated with outbreaks of acute gastroenteritis in the United States, 2000-2004
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DOI：
10.1086/499315
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发表时间：
2006-02-01
影响因子：
6.4
通讯作者：
Monroe, SS
中科院分区：
文献类型：
--
作者：
Blanton, LH;Adams, SM;Monroe, SS
2000年7月至2004年6月期间，地方或州卫生部门将270起急性胃肠炎疫情的粪便标本送往疾病控制和预防中心进行杯状病毒检测。在符合本研究纳入标准的 226 起疫情中，通过逆转录聚合酶链反应和核苷酸测序检测到 184 起（81%）杯状病毒。疗养院、退休中心和医院是最常报告的场所，人与人之间的接触是最常见的传播方式，其次是食源性传播。总体而言，基因组 II 诺如病毒 (NoV) 株最为丰富 (79%)，其次是基因组 I NoV 株 (19%) 和沙波病毒 (2%)。核苷酸序列分析表明，NoV 病毒株具有很大的多样性，并暗示在 2002 年 7 月至 2003 年 6 月期间发生的疫情中出现了一种特定的序列变体。在更常规地使用检测这些病毒的方法之前，我们不会充分认识到杯状病毒对公共卫生的影响，也不会完全评估干预措施。
Between July 2000 and June 2004, fecal specimens from 270 outbreaks of acute gastroenteritis were sent to the Centers for Disease Control and Prevention by local or state health departments for calicivirus testing. Of the 226 outbreaks that met the criteria for inclusion in the present study, caliciviruses were detected in 184 (81%) by reverse-transcription polymerase chain reaction and nucleotide sequencing. Nursing homes, retirement centers, and hospitals were the most frequently reported settings, and person-to-person contact was the most common mode of transmission, followed by foodborne spread. Overall, genogroup II norovirus (NoV) strains were the most abundant (79%), followed by genogroup I NoV strains (19%) and sapovirus (2%). Nucleotide-sequence analysis indicated a great diversity of NoV strains and implicated the emergence of one particular sequence variant in outbreaks occurring between July 2002 and June 2003. The public health impact of caliciviruses will not be fully appreciated, nor will interventions be completely evaluated, until methods to detect these viruses are more routinely used.