Combined endurance/resistance training reduces plasma TNF-α receptor levels in patients with chronic heart failure and coronary artery disease
Combined endurance/resistance training reduces plasma TNF-α receptor levels in patients with chronic heart failure and coronary artery disease
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DOI：
10.1053/euhj.2002.3239
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发表时间：
2002-12-01
影响因子：
39.3
通讯作者：
Brutsaert, DL
中科院分区：
文献类型：
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作者：
Conraads, VM;Beckers, P;Brutsaert, DL
目的慢性心力衰竭（CHF）患者的身体康复可改善运动能力，恢复内皮功能和骨骼肌变化。研究4个月耐力/抗阻综合运动训练对CHF患者细胞因子及其受体的影响。此外，在次最大和最大的运动performance.Methods和结果23例稳定CHF由于冠状动脉疾病（CAD，n= 12）或特发性扩张型心肌病（IDCM，n=11）的变化进行了培训4个月。在基线和4个月后进行血液采样，用于测量白细胞介素（IL）-6肿瘤坏死因子（TNF）-α、可溶性TNF受体（sTNFR 1）和2（sTNFR 2）的血浆浓度（ELISA），以及心肺运动试验。训练诱导总人群sTNFR 1（P=0.02）显著降低，仅CAD组sTNFR 1（P=0.01）和sTNFR 2（P=0.02）浓度显著降低。IL-6和TNF-α水平没有改变。在未经训练的年龄和性别匹配的对照组中，细胞因子浓度保持不变。两组患者的NYHA心功能分级、次最大和最大工作率均显著改善。冠心病患者无氧阈氧摄取量（P=0.002）和最大运动量氧摄取量（P=0.008）明显增加。结论耐力/抗阻联合运动训练对冠心病合并冠心病患者的运动能力有明显的改善作用，并具有抗炎作用。((C)2002年欧洲心脏病学会。由爱思唯尔科技有限公司出版。保留所有权利。
Aims Physical reconditioning of patients with chronic heart failure (CHF) improves exercise capacity and restores endothelial function and skeletal muscle changes. The effects of 4 months combined endurance/resistance exercise training on cytokines and cytokine receptors in patients with CHF were studied. In addition, changes in submaximal and maximal exercise performance were addressed.Methods and Results Twenty-three patients with stable CHF due to coronary artery disease (CAD, n= 12) or idiopathic dilated cardiomyopathy (IDCM, n=11) were trained for 4 months. Blood sampling for measurement of plasma concentrations (ELISA) of interleukin (IL)-6 tumour necrosis factor (TNF)-alpha, soluble TNF receptor; (sTNFR1) and 2 (sTNFR2), as well as cardiopulmonary exercise testing were performed at baseline and after 4 months. Training induced a significant decrease in sTNFR1 (P=0.02) for the total population, and in both sTNFR1 (P=0.01) and sTNFR2 (P=0.02) concentrations for the CAD group only. IL-6 and TNF-alpha levels were not altered. Cytokine concentrations remained unchanged in an untrained age- and sex-matched control group. NYHA functional class, submaximal and maximal workrate were significantly improved in both patient groups. Oxygen uptake at the anaerobic threshold (P=0.002) and at peak exercise increased in the CAD patients only (P=0.008).Conclusion Besides an overall beneficial effect on exercise capacity, combined endurance/resistance exercise training has an anti-inflammatory effect in patients with CHD and CAD.((C) 2002 The European Society of Cardiology. Published by Elsevier Science Ltd. All rights reserved.