Self-assembly of a Peptide [2]Catenane through Ω-Loop Folding
Self-assembly of a Peptide [2]Catenane through Ω-Loop Folding
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DOI：
10.1246/cl.170438
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发表时间：
2017-08-01
影响因子：
1.6
通讯作者：
Fujita, Makoto
中科院分区：
文献类型：
--
作者：
Sawada, Tomohisa;Inomata, Yuuki;Fujita, Makoto
在这项工作中，通过利用Pro-Gly-Pro（PGP）序列折叠成Omega环的强烈趋势来创建肽[2]链烷。包括PGP序列的二位七肽配体1在与Ag+络合时形成肽[2]索烃2。此外，添加/去除Na+引发2和扭曲的大环3之间的可逆结构变化。
In this work, a peptide [2]catenane was created by exploiting the strong tendency of the Pro-Gly-Pro (PGP) sequence to fold into an Omega-loop. Ditopic heptapeptide ligand 1, which includes the PGP sequence, formed peptide [2] catenane 2 on complexation with Ag+. Moreover, addition/removal of Na+ triggered a reversible structural change between 2 and twisted macrocycle 3.