Acute Adverse Events and Postoperative Complications in a Randomized Trial of Preoperative Short-course Radiotherapy Versus Long-course Chemoradiotherapy for T3 Adenocarcinoma of the Rectum Trans-Tasman Radiation Oncology Group Trial (TROG 01.04)
Acute Adverse Events and Postoperative Complications in a Randomized Trial of Preoperative Short-course Radiotherapy Versus Long-course Chemoradiotherapy for T3 Adenocarcinoma of the Rectum Trans-Tasman Radiation Oncology Group Trial (TROG 01.04)
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DOI：
10.1097/sla.0000000000001987
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发表时间：
2017-05-01
影响因子：
9
通讯作者：
Ngan, Samuel Y.
中科院分区：
文献类型：
--
作者：
Ansari, Nabila;Solomon, Michael J.;Ngan, Samuel Y.
目的：比较短期（SC）与长期（LC）术前放疗的随机试验中的急性不良事件（AE）和术后并发症发生率：背景：证据表明，在手术中加入新辅助放疗可以更好地控制直肠癌的局部控制。与SC和LC治疗有一个潜在的急性治疗相关的毒性和增加患者morbidity.Methods：符合条件的患者有临床分期T3直肠腺癌12厘米内的肛门边缘没有转移的证据。SC包括盆腔放疗5 x 5戈伊，1周，早期手术和6个疗程的辅助化疗。LC组50.4戈伊，分28次，5.5周，5-FU静脉滴注，4 ~ 6周手术，4个疗程化疗。无30天手术死亡。LC组至少发生1起AE的百分比在统计学上显著更高（SC，72.3%; LC，99.4%; P
Objective: To compare acute adverse events (AE) and postoperative complication rates in a randomized trial of short-course (SC) versus long-course (LC) preoperative radiotherapy.Background: Evidence demonstrates that adding neoadjuvant radiotherapy to surgery offers better local control in the management of rectal cancer. With both SC and LC therapy there is a potential for acute treatment-related toxicity and increased patient morbidity.Methods: Eligible patients had clinical-stage T3 rectal adenocarcinoma within 12 cm of the anal verge with no evidence of metastasis. SC consisted of pelvic radiotherapy 5 x 5 Gy in 1 week, early surgery and 6 courses of adjuvant chemotherapy. LC was 50.4 Gy administered in 28 fractions during 5.5 weeks, with infusion 5-fluorouracil, surgery in 4 to 6 weeks, and 4 courses of chemotherapy.Results: All SC patients and 93% of LC patients received preoperative planned radiotherapy. Therewas no 30-day operative mortality. A statistically significant higher percentage of at least 1 AE occurred in the LC group (SC, 72.3%; LC, 99.4%; P