Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens
Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens
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DOI：
10.1126/science.1116815
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发表时间：
2005-09-09
期刊：
影响因子：
56.9
通讯作者：
Lahn, BT
中科院分区：
文献类型：
--
作者：
Mekel-Bobrov, N;Gilbert, SL;Lahn, BT
基因ASPM（异常纺锤状小头畸形相关）是大脑大小的特定调节因子，它在导致智人的谱系中的进化是由强烈的正选择驱动的。在这里，我们表明，人类ASPM的一个遗传变异仅出现在大约5800年前，并在强阳性选择下以高频率出现。这些发现，特别是正选择变体的年龄非常小，表明人类大脑仍在经历快速的适应性进化。
The gene ASPM (abnormal spindle-like microcephaly associated) is a specific regulator of brain size, and its evolution in the lineage leading to Homo sapiens was driven by strong positive selection. Here, we show that one genetic variant of ASPM in humans arose merely about 5800 years ago and has since swept to high frequency under strong positive selection. These findings, especially the remarkably young age of the positively selected variant, suggest that the human brain is still undergoing rapid adaptive evolution.