Role of Zinc in the Development/Progression of Alcoholic Liver Disease.
Role of Zinc in the Development/Progression of Alcoholic Liver Disease.
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DOI：
10.1007/s11938-017-0132-4
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发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Cave M
中科院分区：
文献类型：
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作者：
McClain C;Vatsalya V;Cave M
除了饮酒的数量和持续时间外，许多变量在酒精性肝病（ALD）的发生和进展中起作用。一个可以改变的关键因素是饮食/营养。最近我们对营养和ALD相互作用的理解取得了重大进展。本文就锌代谢/治疗ALD的研究进展进行综述。ALD存在主要的锌代谢失调，部分是由摄入和吸收不良、排泄增加和锌转运蛋白（尤其是ZIP14）改变介导的。锌缺乏在ALD的多种机制中起病因学作用，从肠屏障功能障碍到肝细胞凋亡。锌补充剂在纠正这些ALD机制和预防/治疗实验性ALD方面非常有效。目前还没有食品和药物管理局（FDA）批准任何阶段的ALD治疗方法。由于动物和人类数据表明，锌缺乏发生在ALD病程的早期，我们治疗大多数ALD患者每天口服补锌（220毫克硫酸锌，其中含有50毫克元素锌）。
Opinion statementMany variables, aside from the amount and duration of alcohol consumption, play a role in the development and progression of alcoholic liver disease (ALD). One critical factor that can be modified is diet/nutrition. We have made major recent advances in our understanding of the interactions of nutrition and ALD. In this article, we review advances made in zinc metabolism/therapy for ALD. There is major zinc dyshomeostasis with ALD which is mediated, in part, by poor intake and absorption, increased excretion, and altered zinc transporters, especially ZIP14. Zinc deficiency plays an etiologic role in multiple mechanisms of ALD, ranging from intestinal barrier dysfunction to hepatocyte apoptosis. Zinc supplementation is highly effective at correcting these ALD mechanisms and preventing/treating experimental ALD. There is no Food and Drug Administration (FDA) approved therapy for any stage of ALD. Because animal and human data suggest that zinc deficiency occurs early in the course of ALD, we treat most ALD patients with daily oral zinc supplementation (220 mg zinc sulfate which contains 50 mg elemental zinc).