Genome-wide analysis of coordinate expression and evolution of human cis-encoded sense-antisense transcripts
Genome-wide analysis of coordinate expression and evolution of human cis-encoded sense-antisense transcripts
复制标题
DOI：
10.1016/j.tig.2005.04.006
复制
发表时间：
2005-06-01
影响因子：
11.4
通讯作者：
Rowley, JD
中科院分区：
文献类型：
--
作者：
Chen, JJ;Sun, M;Rowley, JD
转录本的正反义配对（SA）是人类基因组基因调控的一种常见模式吗？尽管大约20%的人类基因可能形成SA对，但它们在多大程度上参与反义调控尚不清楚。配对的正义和反义基因同时表达是反义调控的必要步骤和重要指标。在本文中，我们证明了人类SA对倾向于共表达和/或反向表达的频率比偶然预期的要高。此外，共表达和反向表达的SA对表现出惊人的进化守恒模式。这些发现表明，反义调控是人类基因组中常见而重要的基因调控机制。
Is sense-antisense (SA) pairing of transcripts a common mode of gene regulation in the human genome? Although > 20% of human genes might form SA pairs, the extent to which they are involved in antisense regulation is unknown. Simultaneous expression of paired sense and antisense genes is an essential step and an important indicator of antisense regulation. In this article, we demonstrate that human SA pairs tend to be co-expressed and/or inversely expressed more frequently than expected by chance. Moreover, co-expressed and inversely expressed SA pairs exhibit a striking pattern of evolutionary conservation. These findings suggest that antisense regulation is a common and important mechanism of gene regulation in the human genome.