Volumetric evaluation of the relations among the cerebrum, cerebellum and brain stem in young subjects: a combination of stereology and magnetic resonance imaging
Volumetric evaluation of the relations among the cerebrum, cerebellum and brain stem in young subjects: a combination of stereology and magnetic resonance imaging
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DOI：
10.1007/s00276-008-0356-z
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发表时间：
2008-08-01
影响因子：
1.4
通讯作者：
Sahin, Buenyamin
中科院分区：
文献类型：
--
作者：
Ekinci, Nihat;Acer, Niyazi;Sahin, Buenyamin
基于物体的二维切片，使用点网格的卡瓦列里估计量被用于估计三维结构的体积。颅内神经结构各组成部分的大小之间应存在比例关系。体视学方法的体积分数法提供了有关结构组成部分体积关系的信息。我们研究的目的是估计与大脑、小脑和脑干相关的体积和体积分数数据。在这项研究中，对24名没有任何神经症状和体征的土耳其年轻志愿者（12名男性和12名女性）的全脑、大脑、小脑和脑干体积进行了估计。使用体视学方法的点计数法在磁共振（MR）图像上确定了全脑、大脑、小脑和脑干的体积和体积分数。男性和女性的平均（±标准差）全脑、大脑和小脑体积分别为1202.05 ± 103.51、1143.65 ± 106.25立方厘米，1060.0 ± 94.6、1008.9 ± 104.3立方厘米，117.75 ± 10.7、111.83 ± 8.0立方厘米。男性和女性的平均脑干体积分别为24.3 ± 2.89、22.9 ± 4.49立方厘米。我们的结果显示，尽管性别之间没有统计学上的显著差异（P>0.05），但女性受试者的大脑、小脑和脑干体积比男性小。大脑与全脑体积（TBV）之比、小脑与TBV之比以及脑干与TBV之比在男性和女性中分别为88.16%和88.13%、9.8%和9.8%、2.03%和2.03%。小脑与大脑、脑干与大脑以及脑干与小脑的体积比在男性和女性中分别为11.12%和11.16%、2.30%和2.31%、20.7%和20.6%。性别之间的差异没有统计学意义（P>0.05）。我们的结果表明，大脑、小脑和脑干的体积组成没有性别二态性。
The Cavalieri estimator using a point grid is used to estimate the volume of three-dimensional structures based on two-dimensional slices of the object. The size of the components of intracranial neural structures should have proportional relations among them. The volume fraction approach of stereological methods provides information about volumetric relations of the components of structures. The purpose of our study is to estimate the volume and volume fraction data related to the cerebrum, cerebellum and brain stem. In this study, volume of the total brain, cerebrum, cerebellum and brain stem were estimated in 24 Young Turkish volunteers (12 males and 12 females) who are free of any neurological symptoms and signs. The Volume and volume fraction of the total brain, cerebrum, cerebellum and brain stem were determined on magnetic resonance (MR) images using the point-counting approach of stereological methods. The mean (+/-SD) total brain, cerebrum and cerebellum volumes were 1,202.05 +/- 103.51, 1,143.65 +/- 106.25 cm(3) in males and females, 1,060.0 +/- 94.6, 1,008.9 +/- 104.3 cm(3) in males and females, 117.75 +/- 10.7, 111.83 +/- 8.0 cm(3) in males and females, respectively. The mean brain stem volumes were 24.3 +/- 2.89, 22.9 +/- 4.49 cm(3) in males and females, respectively. Our results revealed that female subjects have less cerebral, cerebellar and brain stem volumes compared to males, although there was no statistically significant difference between genders (P > 0.05). The volume ratio of the cerebrum to total brain volume (TBV), cerebellum to TBV and brain stem to TBV were 88.16 and 88.13% in males and females, 9.8 and 9.8% in males and females, 2.03 and 2.03% in males and females, respectively. The Volume ratio of the cerebellum to cerebrum, brain stein to cerebrum and brain stein to cerebellum were 11.12 and 11.16% in males and females, 2.30 and 2.31% in males and females, 20.7 and 20.6% in males and females, respectively. The difference between the genders was not statistically significant (P > 0.05). Our results revealed that the volumetric composition of the cerebrum, cerebellum and brain stem does not show sexual dimorphism.