The small intestinal mucosa in dermatitis herpetiformis. II. Relationship of the small intestinal lesion to gluten.
The small intestinal mucosa in dermatitis herpetiformis. II. Relationship of the small intestinal lesion to gluten.
复制标题
疱疹样皮炎的小肠粘膜。
DOI：
10.1016/s0016-5085(71)80115-4
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发表时间：
1971
期刊：
影响因子：
29.4
通讯作者：
C. Rubin
中科院分区：
文献类型：
--
作者：
Wilfred M. Weinstein;J. Brow;F. Parker;C. Rubin
6例疱疹样皮炎（DH）和“平坦”近端肠道病变的患者被置于严格的无麸质饮食2 1/2至6个月。在面筋撤除之前和之后，从十二指肠的整个长度和空肠的前两个袢获得多个活组织检查。所有6例患者的绒毛结构均得到显著改善。6例患者中有3例有明确的脂肪肝，在停用谷蛋白后有所改善。结论：这6例DH患者近端肠粘膜平坦，均为乳糜泻。
Six patients with dermatitis herpetiformis (DH) and “flat” proximal intestinal lesions were placed on strict gluten-free diets for 2 1/2 to 6 months. Multiple biopsies were obtained from the whole length of the duodenum and up to the first two loops of jejunum, before and after gluten withdrawal. A striking improvement in villous architecture occurred in all 6 patients. Three of the 6 patients had definite steatorrhea which improved after gluten withdrawal. It is concluded that these 6 patients with DH and flat proximal intestinal mucosa have celiac sprue.