T-independent IgA responses to microbial polysaccharides.
T-independent IgA responses to microbial polysaccharides.
复制标题
对微生物多糖的 T 依赖性 IgA 反应。
DOI:
10.1007/978-1-4615-1267-7_32
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发表时间:
2001
影响因子:
--
通讯作者:
Wang,D
中科院分区:
文献类型:
--
作者:
Wang,D
There is accumulating evidence indicating the presence in vivo of T -independent routes of IgA response in addition to the conventional T-dependent IgA response. Factors influencing these alternative pathways of IgA responses may include the structural characteristics of a stimulating antigen, the nature of responding B cells, and the microenvironment. The structural complexity of polysaccharide antigens has made it difficult to summarize a general scheme for the antibody responses they induce. Instead, one may expect that each individual polysaccharide may be able to create a unique microenvironment by activation of specific cell populations in the repertoires of non-T cell types. A specific pattern of B cell response may thus be elicited by TI stimulation. Recognition of such a unique property of a TI antigens is necessary for us to better understand the T -independent IgA response. Information obtained may have an impact on the development of vaccination strategies directed at the mucosal immunity mediated by IgA antibodies.
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DOI:
--
发表时间:
1976
影响因子:
11.1
作者:
H. Dintzis;R. Dintzis;B. Vogelstein
通讯作者:
B. Vogelstein
影响因子:
--
作者:
Kagnoff,MF;Murray,PD
通讯作者:
Murray,PD
影响因子:
--
作者:
N. Bos;J. Bun;H. Bijma;E. Cebra;J. Cebra;G. Deenen;M. Van Der Cammen;F. Kroese
通讯作者:
F. Kroese
DOI:
--
发表时间:
1985
期刊:
影响因子:
--
作者:
E. Seillès;D. Vuitton;P. Sava;P. Claude;J. Panouse;A. Roche;D. Delacroix
通讯作者:
D. Delacroix
影响因子:
3.6
作者:
Chen,HT;Makover,SD;Kabat,EA
通讯作者:
Kabat,EA