T-independent IgA responses to microbial polysaccharides.

T-independent IgA responses to microbial polysaccharides.
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对微生物多糖的 T 依赖性 IgA 反应。

DOI:
10.1007/978-1-4615-1267-7_32
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发表时间:
2001
影响因子:
--
通讯作者:
Wang,D
Wang,D
中科院分区:
医学4区
文献类型:
--
作者:
Wang,D

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There is accumulating evidence indicating the presence in vivo of T -independent routes of IgA response in addition to the conventional T-dependent IgA response. Factors influencing these alternative pathways of IgA responses may include the structural characteristics of a stimulating antigen, the nature of responding B cells, and the microenvironment. The structural complexity of polysaccharide antigens has made it difficult to summarize a general scheme for the antibody responses they induce. Instead, one may expect that each individual polysaccharide may be able to create a unique microenvironment by activation of specific cell populations in the repertoires of non-T cell types. A specific pattern of B cell response may thus be elicited by TI stimulation. Recognition of such a unique property of a TI antigens is necessary for us to better understand the T -independent IgA response. Information obtained may have an impact on the development of vaccination strategies directed at the mucosal immunity mediated by IgA antibodies.
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影响因子: 11.1
作者:
H. Dintzis;R. Dintzis;B. Vogelstein
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IgA 和 IgM 抗多糖反应的 T 依赖性诱导。
DOI: 10.1007/978-1-4684-5344-7_18
发表时间: 1987
影响因子: --
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DOI: --
发表时间: 1994
影响因子: --
作者:
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DOI: --
发表时间: 1985
期刊:
影响因子: --
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来自 C58/J 和 C57BL/10 裸鼠的硬脂酰异麦芽四糖单克隆抗体的免疫化学研究。
DOI: 10.1016/0161-5890(87)90174-x
发表时间: 1987
影响因子: 3.6
作者:
Chen,HT;Makover,SD;Kabat,EA
通讯作者: Kabat,EA