Comparison of tumour necrosis factor and endothelin-1 between essential and renal hypertensive patients
Comparison of tumour necrosis factor and endothelin-1 between essential and renal hypertensive patients
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DOI：
10.1038/sj.jhh.1000596
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发表时间：
1998-06-01
影响因子：
2.7
通讯作者：
Cerasola, G
中科院分区：
文献类型：
--
作者：
Cottone, S;Vadala, A;Cerasola, G
本研究旨在比较伴或不伴肾功能衰竭的高血压患者以及血压正常的健康受试者的肿瘤坏死因子-α (TNF α) 和血浆内皮素 1 (ET-1) 的循环水平。研究人群包括21名健康正常血压受试者和22名高血压患者、II型原发性高血压患者、11名高血压合并慢性肾功能衰竭（CRF）患者。检测所有受试者的血浆ET-1水平、血清TNFα和肌酐、肌酐清除率、24小时尿白蛋白排泄量（UAE），并进行24小时血压监测。患有和不患有 CRF 的高血压患者的诊室血压相似。然而，CRF患者的24小时血压高于原发性高血压且肾功能正常的患者。高血压患者的ET-1水平高于血压正常者（P < 0.01）。患有 CRF 的高血压患者血清 TNF α 和 ET-1 水平高于原发性高血压患者和血压正常受试者。 22例高血压患者中，TNFα水平与血清肌酐呈负相关（r = 0.60；P < 0.01），ET-1水平与UAE呈正相关（r = 0.47，P < 0.05）。本研究表明，高血压患者，特别是肾功能不全患者，表现出血液中ET-1和TNF α水平异常。这些因素可能导致心血管和肾脏损伤。
The present study was performed to compare circulating levels of tumour necrosis factor-alpha (TNF alpha) and plasma endothelin 1 (ET-1), of hypertensive patients with or without renal failure and with those of normotensive healthy subjects. The study population consisted of 21 healthy normotensive subjects and 22 hypertensive patients, II with essential hypertension, and 11 with hypertension and chronic renal failure (CRF).Plasma ET-1 levels, serum TNF alpha and creatinine, creatinine clearance, 24-h urinary albumin excretion (UAE) were assayed, and 24-h blood pressure monitoring was obtained in all subjects. Office blood pressure was similar between hypertensive patients with and without CRF. However, 24-h blood pressure was greater in patients with CRF than in those with essential hypertension and normal renal function.Patients with hypertension manifested greater ET-1 levels than normotensive subjects (P < 0.01). Serum TNF alpha and ET-1 levels were higher in hypertensive patients with CRF than in patients with essential hypertension and normotensive subjects. In the 22 hypertensive patients, TNF alpha levels were negatively correlated with serum creatinine (r = 0.60; P < 0.01), and ET-1 levels were positively correlated with UAE (r = 0.47, P < 0.05).The present study has shown that hypertensive patients, and particularly those with renal insufficiency, manifest abnormal blood levels of ET-1 and TNF alpha. These factors could contribute to both cardiovascular and renal damage.