A chemically-defined medium supporting growth and providing cells converting compactin to pravastatin
A chemically-defined medium supporting growth and providing cells converting compactin to pravastatin
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一种化学成分确定的培养基，支持生长并提供细胞将康帕汀转化为普伐他汀
DOI：
10.1038/sj.jim.2900602
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发表时间：
1999
影响因子：
3.4
通讯作者：
A. Demain
中科院分区：
文献类型：
--
作者：
Y. Peng;E. A. Walker;J. C. Davis;A. Demain
Actinomadurasp菌株2966将康帕汀转化为普伐他汀，需要维生素来支持其生长。添加叶酸、硫胺素和氰钴胺允许在化学成分确定的培养基中生长。在化学成分确定的培养基中生长的细胞能够将康伐他汀转化为普伐他汀，就像在复杂培养基中生长的细胞一样。
Actinomadurasp strain 2966, which converts compactin to pravastatin, requires vitamins to support its growth. Addition of folic acid, thiamine and cyanocobalamine allowed growth in chemically-defined medium. Cells grown in a chemically-defined medium were as capable of converting compactin to pravastatin as cells grown in a complex medium.