The HCV serum proteome: a search for fibrosis protein markers
The HCV serum proteome: a search for fibrosis protein markers
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DOI：
10.1111/j.1365-2893.2009.01083.x
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发表时间：
2009-06-01
影响因子：
2.5
通讯作者：
Van Vlierberghe, H.
中科院分区：
文献类型：
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作者：
Cheung, K. J.;Tilleman, K.;Van Vlierberghe, H.
肝纤维化/肝硬化是丙型肝炎病毒（HCV）感染患者的严重健康问题，目前通过侵入性肝活检来诊断。本研究的目的是基于蛋白质组学在不同纤维化程度（METAVIR F0-F4）的 HCV 患者血清中寻找有用的纤维化标志物。通过二维凝胶电泳创建血清蛋白质组谱。通过单变量分析对不同程度的纤维化（F0-F4）以及早期（F0F1）和晚期（F2F3F4）纤维化之间的概况进行分析（P
Liver fibrosis/cirrhosis is a serious health issue in hepatitis C virus (HCV-) infected patients and is currently diagnosed by the invasive liver biopsy. The aim of this study was to find useful fibrosis markers in HCV-patients' sera of different fibrosis degrees (METAVIR F0-F4) based on proteomics. Serum proteome profiles were created by two-dimensional gel electrophoresis. Profiles were analysed between different degrees of fibrosis (F0-F4) and between early (F0F1) and late (F2F3F4) fibrosis by univariate analyses (P